@article{HBSN10570,
author = {Jimme K. Wiggers and Wouter W. te Riele and Tristan H. van Dongen and Joanne Verheij and Olivier R.C. Busch and Thomas M. van Gulik},
title = {Combined liver and extrahepatic bile duct resection for biliary invasion of colorectal metastasis: a case-cohort analysis and systematic review},
journal = {Hepatobiliary Surgery and Nutrition},
volume = {5},
number = {4},
year = {2016},
keywords = {},
abstract = {Background: Colorectal liver metastases (CRLMs) with biliary invasion can be treated with a combined liver and extrahepatic bile duct resection. The aim of this study was to analyze outcomes of this procedure in a case-cohort analysis and systematic review.
Methods: Consecutive patients who underwent a major liver resection for CRLM between 2003 and 2013 were selected from a single center prospective database, comparing patients with and without biliary invasion. A specific and a general search strategy were used to identify relevant articles in the systematic review.
Results: Ten patients (13.2%) underwent combined liver and extrahepatic bile duct resection for CLRM with biliary invasion, among 76 patients included. An R0 resection was achieved in five of ten patients (50%); one of ten patients died postoperatively. Median overall survival was 19 months among patients with biliary invasion, versus 106 months among patients without biliary invasion (P=0.12). The systematic review yielded a large variability in 5-year survival after resection of CLRM with biliary invasion, ranging between 33–80%.
Conclusions: Surgical resection of CLRM with central biliary invasion is feasible, but survival in these patients tends to be lower due to a high rate of non-radical resections.},
issn = {2304-389X}, url = {https://hbsn.amegroups.org/article/view/10570}
}