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Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies

   
@article{HBSN17503,
	author = {Kévin Bévant and Cédric Coulouarn},
	title = {Landscape of genomic alterations in hepatocellular carcinoma: current knowledge and perspectives for targeted therapies},
	journal = {Hepatobiliary Surgery and Nutrition},
	volume = {6},
	number = {6},
	year = {2017},
	keywords = {},
	abstract = {Hepatocellular carcinoma (HCC) is a deadly cancer worldwide characterized by a rising incidence and limited therapeutic options (1). HCC is associated with multiple risk factors, including chronic hepatitis B and C (HBV/HCV), alcohol intake, aflatoxin B1 exposure, diabetes and obesity. In addition, liver carcinogenesis is a long and multistep process associated with the accumulation of multiple genetic and epigenetic alterations resulting in tumor heterogeneity (1). Thus, each HCC tumor is characterized by a unique molecular fingerprint made of a specific combination of somatic alterations (2).},
	issn = {2304-389X},	url = {https://hbsn.amegroups.org/article/view/17503}
}