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Increased mutant KRAS gene dosage drives pancreatic cancer progression: evidence for wild-type KRAS as a tumor suppressor?

   
@article{HBSN20635,
	author = {Oliver A. Kent},
	title = {Increased mutant KRAS gene dosage drives pancreatic cancer progression: evidence for wild-type KRAS as a tumor suppressor?},
	journal = {Hepatobiliary Surgery and Nutrition},
	volume = {7},
	number = {5},
	year = {2018},
	keywords = {},
	abstract = {RAS genes are most commonly associated with gain-of function mutations that promote oncogenic behavior. Activating mutations in KRAS occur in 90–95% cases of pancreatic ductal adenocarcinoma (PDAC) a deadly and highly metastatic disease. Currently the fourth leading cause of cancer death in the United States, PDAC presents with a dismal 5-year survival rate of less than 5% (1). Acquisition of KRAS mutation is regarded as an initiating event in the development of PDAC, but what is the role of the wild-type KRAS allele in disease initiation and progression?},
	issn = {2304-389X},	url = {https://hbsn.amegroups.org/article/view/20635}
}