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Heterogenous responses to nivolumab in a single metastatic nodule in hepatocellular carcinoma: role of salvage surgery

   
@article{HBSN29362,
	author = {Hyun Yang and Pil Soo Sung and Jaejun Lee and Seung Kew Yoon and Eun Sun Jung and Cheon-Soo Park and Si Hyun Bae},
	title = {Heterogenous responses to nivolumab in a single metastatic nodule in hepatocellular carcinoma: role of salvage surgery},
	journal = {Hepatobiliary Surgery and Nutrition},
	volume = {8},
	number = {5},
	year = {2019},
	keywords = {},
	abstract = {A recent report demonstrated immune heterogeneity of hepatocellular carcinoma (HCC) (1). The objective response rates of sorafenib-treated global and Asian patients by nivolumab, the monoclonal antibody to programmed cell death protein-1, were only 14% and 15%, respectively (2,3). However, there is a lack of reports demonstrating the heterogenous responses within single tumor to nivolumab. Here, we show a pathologically confirmed, heterogenous response to nivolumab within a single metastatic tumor from HCC. In these circumstances, surgery can be considered as an option to cure the disease.},
	issn = {2304-389X},	url = {https://hbsn.amegroups.org/article/view/29362}
}