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Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma

   
@article{HBSN3556,
	author = {Ying-Ying Lee and Myth T.S. Mok and Alfred Sze-Lok Cheng},
	title = {Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma},
	journal = {Hepatobiliary Surgery and Nutrition},
	volume = {3},
	number = {2},
	year = {2014},
	keywords = {},
	abstract = {Error-prone integration of the hepatitis B virus X protein (HBx) into the hepatocellular genome generates a multitude of mutants exerting diverse effects on the development and progression of hepatocellular carcinoma (HCC). A recent study by Lai and colleagues revealed the disparate regulatory activity of clinically-predominant HBx mutants towards hypoxia-inducible factor-1α (HIF-1α), a central regulator of tumor angiogenesis, proliferation, metastasis and differentiation. These findings have shed insight into specific viral contribution of hypoxic response during hepatocarcinogenesis.},
	issn = {2304-389X},	url = {https://hbsn.amegroups.org/article/view/3556}
}