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Predicting responsiveness to sorafenib: can the determination of FGF3/FGF4 amplifications enrich for clinical benefit?

   
@article{HBSN4261,
	author = {James J. Harding and Ghassan K. Abou-Alfa},
	title = {Predicting responsiveness to sorafenib: can the determination of FGF3/FGF4 amplifications enrich for clinical benefit?},
	journal = {Hepatobiliary Surgery and Nutrition},
	volume = {3},
	number = {4},
	year = {2014},
	keywords = {},
	abstract = {A small proportion of patients with advanced hepatocellular carcinoma harbor FGF3/4 gene amplifications in an 11q13 amplicon. A recent report suggests that the presence of this alteration might enrich for sensitivity to sorafenib. Further, there is growing evidence that interference with the FGF/FGFR axis has therapeutic potential in patients with advanced hepatocellular carcinoma.},
	issn = {2304-389X},	url = {https://hbsn.amegroups.org/article/view/4261}
}