The role of selective internal radiotherapy with Y-90 resin microsphere in first-line therapy for hepatic colorectal metastases

The liver is the primary site of metastases in colorectal cancer (CRC) because the majority of the venous mesenteric drainage enters the hepatic portal venous circulation. More than 50% of patients with CRC will develop hepatic metastases over the course of their life. This ultimately leads to death more than two-thirds of these patients (1).