Optimal timing of reoperation for postoperatively diagnosed T2 gallbladder cancer: a retrospective multicenter cohort study

The optimal timing of reoperation for postoperatively diagnosed T2 gallbladder cancer is 4 to 8 weeks after the initial cholecystectomy. Early reoperation is associated with worse perioperative outcomes, while delayed reoperation is associated with higher risk of recurrence.

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Independent risk factors for clinically relevant postoperative pancreatic fistula after robotic pancreatoduodenectomy: the protective role of the modified Blumgart pancreatojejunostomy in a single surgeon retrospective cohort of 220 cases

In a single-surgeon series of 220 robotic pancreatoduodenectomies, standardization of the modified Blumgart pancreatojejunostomy significantly reduced clinically relevant pancreatic fistula rates. Risk-adjusted learning curve analysis showed earlier achievement of proficiency and mastery, supporting routine adoption of this anastomosis during robotic program implementation.

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When is enough enough?—predicting adequacy of portal vein embolization for hypertrophy of the future liver remnant in the age of liver venous deprivation

Patients with pre-PVE sFLR <19% and those with gross liver abnormalities or planned for staged or extended right hepatectomy are unlikely to achieve adequate liver remnant hypertrophy with PVE and may benefit from other measures like LVD.

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Systematic review and meta-analysis of robotic versus laparoscopic radical cholecystectomy for gallbladder cancer

Robotic surgery is shown to be safe, effective and appears to have better short-term outcomes in comparison to laparoscopic radical cholecystectomy. However, further studies and data are required to validate robotic radical cholecystectomy as the safe and feasible approach.

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Monitoring with plasma apolipoprotein A2-isoforms can predict developing new-onset steatotic liver disease caused by pancreatic exocrine insufficiency following pancreatectomy

New-onset steatotic liver disease (SLD) is increasingly reported after pancreatectomy. In this retrospective study, low plasma ApoA2-AT/AT levels (<9.58 µg/mL) significantly correlated with post-operative SLD and were an independent risk factor. ApoA2 isoforms represent a useful biomarker for assessing pancreatic exocrine function and predicting SLD.

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Diagnostic and management guidelines for biliary atresia in 2025

This consensus summarizes the latest literature on BA and brings together 23 opinions and recommendations from 50 experts from both East and West. International guidelines for BA can provide guidance on current practice for surgeons, patients, medical societies, hospital administrators, and relevant community groups.

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Impact of metabolic dysfunction-associated steatotic liver disease on long-term prognosis in hepatocellular carcinoma patients undergoing hepatectomy

This study reveals that metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant risk factor for poor recurrence-free survival (RFS) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing hepatectomy, emphasizing the importance of preoperative MASLD diagnosis for prognosis guidance.

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Enhanced long-term outcomes with laparoscopic bariatric surgery in patients with severe obesity and metabolic dysfunction-associated steatotic liver disease: a retrospective cohort study

In this population-based study, laparoscopic surgery is associated with lower risk of liver and non-liver adverse outcomes, as well as lower healthcare utilization and pharmacy costs in patients with metabolic dysfunction-associated steatotic liver disease and severe obesity as compared to open surgery.

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Prediction of postoperative early recurrence and response to adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma with microvascular invasion after hepatectomy: a multicenter study

A new calculator, the DCDAM score, utilizes diameter, cirrhosis, differentiation, AFP, and MVI grade to accurately predict early recurrence of HCC with MVI. Patients in the high-risk group (DCDAM score > 169) experience poor RFS and OS and respond well to postoperative adjuvant TACE.

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Does neoadjuvant therapy reduce pancreatic fistula after pancreatoduodenectomy and distal pancreatectomy?—a systematic review and meta-analysis

This systematic review and meta-analysis found that neoadjuvant therapy significantly reduces the risk of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, likely due to induced pancreatic fibrosis. It suggests potential for improved surgical outcomes but emphasizes the need for individualized treatment based on predicted tumor response.

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A systematic review of methodology in nutritional trials in patients undergoing pancreatoduodenectomy

There is evidence of widespread variation in the methodology amongst published trials of nutritional interventions in patients undergoing pancreatoduodenectomy. This makes comparing the effect of these different nutritional interventions on postoperative outcomes difficult and has implications for design of future nutritional trials in this area.

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Precision transarterial chemoembolization in hepatocellular carcinoma: patient selection, standardized techniques, and quantitative evaluation

With the aim to enhance quality control and standardize TACE procedures, the concept of "precision TACE" is introduced by ISMIO, emphasizing standardized angiography, superselective catheterization and embolization, appropriate selection of embolic agents, determination of optimal embolization endpoints, and evaluation for efficacy immediately post-TACE.

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Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)

This updated 2024 Chinese expert consensus details conversion and perioperative strategies for hepatocellular carcinoma (HCC). It refines definitions and integrates new systemic and locoregional therapies with surgery to downstage tumors for resection. A multidisciplinary collaboration approach is emphasized to improve long-term survival for HCC patients.

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New Impact Factor for HepatoBiliary Surgery and Nutrition: 8.1

We are pleased to announce that HepatoBiliary Surgery and Nutrition (HBSN) has obtained its latest impact factor for the 2025 citation year: 8.1.

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Association of a novel glycemic control index, time in range, with infectious complications after pancreatectomy

The study provides useful information on the relationship between time-in-range and organ/space surgical site infection after pancreatectomy. The findings indicate that a time-in-range <75% during the first week after pancreatectomy is a significant risk factor for organ/space surgical site infection.

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Interviews with Outstanding Authors (2026)

In 2026, many HBSN authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

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EREG-secreting THBS1+ tissue monocytes are recruited by C5a to promote rapid liver regeneration in patients and mice during the ALPPS procedure

The first report of human liver local immune microenvironment changes during rapid regeneration induced by ALPPS. THBS1+ tissue monocytes recruit by C5a are significantly enriched in FLR resulting a shift from a macrophage-enriched to monocyte-enriched local immune environment, promoting hepatocyte proliferation via EREG- EGFR interactions.

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Impact of adjuvant therapy on survival outcomes in resected gallbladder cancer: a systematic review and meta-analysis

This meta-analysis assesses the impact of adjuvant therapies (chemotherapy, radiotherapy, and chemoradiotherapy) on survival outcomes in resectable gallbladder cancer. The results suggest that chemoradiotherapy is associated with improved survival, especially in patients with high-risk features, highlighting the need for personalized treatment strategies.

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Phase II trial of hepatic arterial infusion chemotherapy plus bevacizumab and toripalimab for advanced biliary tract cancers: efficacy, safety, and exploratory analysis

HAIC combined with bevacizumab and toripalimab yielded encouraging outcomes as a first-line treatment for advanced BTCs in terms of ORR, PFS, OS, and an acceptable safety profile. Therefore, the triple combination therapy may be an improved first-line treatment for advanced BTC.

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Factors associated with textbook outcome after robotic-assisted pancreatoduodenectomy: a single surgeon’s retrospective cohort

In a single-surgeon cohort of RPD patients, TO was achieved in 57.0% of all patients and in 63.2% after surgeon’s learning curve. Surgeon’s learning curve, ASA score, concomitant diabetes, and dilated pancreatic duct (>3mm) were independently associated with TO.

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AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

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Reviewer of the Month (2026)

In 2026, HBSN reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

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