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Impact of metabolic dysfunction-associated steatotic liver disease on long-term prognosis in hepatocellular carcinoma patients undergoing hepatectomy

This study reveals that metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant risk factor for poor recurrence-free survival (RFS) and overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing hepatectomy, emphasizing the importance of preoperative MASLD diagnosis for prognosis guidance.

Enhanced long-term outcomes with laparoscopic bariatric surgery in patients with severe obesity and metabolic dysfunction-associated steatotic liver disease: a retrospective cohort study

In this population-based study, laparoscopic surgery is associated with lower risk of liver and non-liver adverse outcomes, as well as lower healthcare utilization and pharmacy costs in patients with metabolic dysfunction-associated steatotic liver disease and severe obesity as compared to open surgery.

Prediction of postoperative early recurrence and response to adjuvant transcatheter arterial chemoembolization in hepatocellular carcinoma with microvascular invasion after hepatectomy: a multicenter study

A new calculator, the DCDAM score, utilizes diameter, cirrhosis, differentiation, AFP, and MVI grade to accurately predict early recurrence of HCC with MVI. Patients in the high-risk group (DCDAM score > 169) experience poor RFS and OS and respond well to postoperative adjuvant TACE.

Does neoadjuvant therapy reduce pancreatic fistula after pancreatoduodenectomy and distal pancreatectomy?—a systematic review and meta-analysis

This systematic review and meta-analysis found that neoadjuvant therapy significantly reduces the risk of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, likely due to induced pancreatic fibrosis. It suggests potential for improved surgical outcomes but emphasizes the need for individualized treatment based on predicted tumor response.

A systematic review of methodology in nutritional trials in patients undergoing pancreatoduodenectomy

There is evidence of widespread variation in the methodology amongst published trials of nutritional interventions in patients undergoing pancreatoduodenectomy. This makes comparing the effect of these different nutritional interventions on postoperative outcomes difficult and has implications for design of future nutritional trials in this area.

Precision transarterial chemoembolization in hepatocellular carcinoma: patient selection, standardized techniques, and quantitative evaluation

With the aim to enhance quality control and standardize TACE procedures, the concept of "precision TACE" is introduced by ISMIO, emphasizing standardized angiography, superselective catheterization and embolization, appropriate selection of embolic agents, determination of optimal embolization endpoints, and evaluation for efficacy immediately post-TACE.

Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition)

This updated 2024 Chinese expert consensus details conversion and perioperative strategies for hepatocellular carcinoma (HCC). It refines definitions and integrates new systemic and locoregional therapies with surgery to downstage tumors for resection. A multidisciplinary collaboration approach is emphasized to improve long-term survival for HCC patients.

New Impact Factor for HepatoBiliary Surgery and Nutrition: 8.1

We are pleased to announce that HepatoBiliary Surgery and Nutrition (HBSN) has obtained its latest impact factor for the 2025 citation year: 8.1.

Association of a novel glycemic control index, time in range, with infectious complications after pancreatectomy

The study provides useful information on the relationship between time-in-range and organ/space surgical site infection after pancreatectomy. The findings indicate that a time-in-range <75% during the first week after pancreatectomy is a significant risk factor for organ/space surgical site infection.

Interviews with Outstanding Authors (2026)

In 2026, many HBSN authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

EREG-secreting THBS1+ tissue monocytes are recruited by C5a to promote rapid liver regeneration in patients and mice during the ALPPS procedure

The first report of human liver local immune microenvironment changes during rapid regeneration induced by ALPPS. THBS1+ tissue monocytes recruit by C5a are significantly enriched in FLR resulting a shift from a macrophage-enriched to monocyte-enriched local immune environment, promoting hepatocyte proliferation via EREG- EGFR interactions.

Impact of adjuvant therapy on survival outcomes in resected gallbladder cancer: a systematic review and meta-analysis

This meta-analysis assesses the impact of adjuvant therapies (chemotherapy, radiotherapy, and chemoradiotherapy) on survival outcomes in resectable gallbladder cancer. The results suggest that chemoradiotherapy is associated with improved survival, especially in patients with high-risk features, highlighting the need for personalized treatment strategies.

Phase II trial of hepatic arterial infusion chemotherapy plus bevacizumab and toripalimab for advanced biliary tract cancers: efficacy, safety, and exploratory analysis

HAIC combined with bevacizumab and toripalimab yielded encouraging outcomes as a first-line treatment for advanced BTCs in terms of ORR, PFS, OS, and an acceptable safety profile. Therefore, the triple combination therapy may be an improved first-line treatment for advanced BTC.

Factors associated with textbook outcome after robotic-assisted pancreatoduodenectomy: a single surgeon’s retrospective cohort

In a single-surgeon cohort of RPD patients, TO was achieved in 57.0% of all patients and in 63.2% after surgeon’s learning curve. Surgeon’s learning curve, ASA score, concomitant diabetes, and dilated pancreatic duct (>3mm) were independently associated with TO.

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

Reviewer of the Month (2026)

In 2026, HBSN reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

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Vol 15, No 4 (August, 2026)

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Original Article

Liver donor macrosteatosis is associated with adverse long-term outcomes exclusively in metabolic dysfunction-associated steatotic liver disease recipients: a U.S. transplant registry analysis over the last decade

Leandro Sierra, Butros Fakhoury, Kanisha Bahierathan, Maria Saavedra-Martinez, Maria Ortega Abad, Lily Liu, Vinay Jahagirdar, Pojsakorn Danpanichkul, Katherine M. Cooper, Luis Antonio Diaz, Juan Pablo Arab

HepatoBiliary Surgery and Nutrition

2026;

(4)

:97

(01 August 2026)

PDF Full Text (31) Reporting Checklist Peer Review File COI Form Open Access

Liver grafts with >30% macrovesicular steatosis were associated with significantly lower early and long-term graft survival in MASLD recipients but showed no such association in MetALD or ALD recipients. Our study suggests steatotic graft allocation in liver transplantation should be guided by recipient SLD subtype.

Optimal timing of reoperation for postoperatively diagnosed T2 gallbladder cancer: a retrospective multicenter cohort study

Yeshong Park, Jinju Kim, MeeYoung Kang, Boram Lee, Hae Won Lee, Jai Young Cho, Ho-Seong Han, Dae Wook Hwang, Chang Moo Kang, Chi-Young Jeong, Wan-Joon Kim, Yoo-Seok Yoon

HepatoBiliary Surgery and Nutrition

2026;

(4)

:98

(01 August 2026)

PDF Full Text (23) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The optimal timing of reoperation for postoperatively diagnosed T2 gallbladder cancer is 4 to 8 weeks after the initial cholecystectomy. Early reoperation is associated with worse perioperative outcomes, while delayed reoperation is associated with higher risk of recurrence.

Independent risk factors for clinically relevant postoperative pancreatic fistula after robotic pancreatoduodenectomy: the protective role of the modified Blumgart pancreatojejunostomy in a single surgeon retrospective cohort of 220 cases

Abdallah Iben-Khayat, Amaury Facque, Guillaume Beraud, Baudouin Thebault, Willy Serge Mfam, Jean-Emanuel Langdorph, Olivier Saint-Marc, Haythem Najah

HepatoBiliary Surgery and Nutrition

2026;

(4)

:99

(01 August 2026)

PDF Full Text (13) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

In a single-surgeon series of 220 robotic pancreatoduodenectomies, standardization of the modified Blumgart pancreatojejunostomy significantly reduced clinically relevant pancreatic fistula rates. Risk-adjusted learning curve analysis showed earlier achievement of proficiency and mastery, supporting routine adoption of this anastomosis during robotic program implementation.

When is enough enough?—predicting adequacy of portal vein embolization for hypertrophy of the future liver remnant in the age of liver venous deprivation

Antony Haddad, Reed I. Ayabe, Andrew D. Newton, Harufumi Maki, Mateo Lendoire, Yun Shin Chun, Ching-Wei D. Tzeng, Bruno C. Odisio, Steven Y. Huang, Jean-Nicolas Vauthey, Timothy E. Newhook, Hop S. Tran Cao

HepatoBiliary Surgery and Nutrition

2026;

(4)

:100

(01 August 2026)

PDF Full Text (16) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Patients with pre-PVE sFLR <19% and those with gross liver abnormalities or planned for staged or extended right hepatectomy are unlikely to achieve adequate liver remnant hypertrophy with PVE and may benefit from other measures like LVD.

Systematic review and meta-analysis of robotic versus laparoscopic radical cholecystectomy for gallbladder cancer

Hiang Jin Tan, Michelle Shi Qing Khoo, Xuan Han Koh, Nita Thiruchelvam, Adrian Kah Heng Chiow

HepatoBiliary Surgery and Nutrition

2026;

(4)

:101

(01 August 2026)

PDF Full Text (25) Reporting Checklist Peer Review File COI Form Open Access

Robotic surgery is shown to be safe, effective and appears to have better short-term outcomes in comparison to laparoscopic radical cholecystectomy. However, further studies and data are required to validate robotic radical cholecystectomy as the safe and feasible approach.

Monitoring with plasma apolipoprotein A2-isoforms can predict developing new-onset steatotic liver disease caused by pancreatic exocrine insufficiency following pancreatectomy

Akira Matsushita, Takashi Ono, Daigo Yoshimori, Akira Hamaguchi, Takahiro Murokawa, Junji Ueda, Tetsuya Shimizu, Yoichi Kawano, Masato Yoshioka, Mampei Kawashima, Yoshiharu Nakamura, Kengo Nagashima, Yuta Hasegawa, Tomonari Kiriyama, Keiko Takeuchi, Ayumi Kashiro, Kazufumi Honda, Hiroshi Yoshida

HepatoBiliary Surgery and Nutrition

2026;

(4)

:102

(01 August 2026)

PDF Full Text (13) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

New-onset steatotic liver disease (SLD) is increasingly reported after pancreatectomy. In this retrospective study, low plasma ApoA2-AT/AT levels (<9.58 µg/mL) significantly correlated with post-operative SLD and were an independent risk factor. ApoA2 isoforms represent a useful biomarker for assessing pancreatic exocrine function and predicting SLD.

Clinical Practice Guideline

Diagnostic and management guidelines for biliary atresia in 2025

Liang Ge, Jixin Yang, Tengfei Li, Tianqi Zhu, Mark Davenport, Claus Petersen, Taylor Jacobs, Robin Petroze, Jianshe Wang, Kenneth Kak Yuen Wong, Zhibo Zhang, Wei Gao, Sainan Shu, Ping Yin, Shujian Zhang, Yajun Chen, Zhibao Lv, Shuguang Jin, Zhe Wen, Bin Wang, Weibing Tang, Jinfa Tou, Qiang Yin, Bin Xu, Linsheng Zhao, Wanfu Li, Xueqiang Yan, Shengqiao Zhao, Yuanmei Liu, Xiang Liu, Hua Huang, Shungen Huang, Pu Yu, Hongxia Ren, Yingchao Li, Huizhong Niu, Alimujiang Abudureyimu, Xin Li, Shaowen Liu, Rongjuan Sun, Heying Yang, Mingman Zhang, Xiaoke Dai, Mureo Kasahara, George V. Mazariegos, Yanjun Shi, Masaki Nio, Thanh Liem Nguyen, Vincent Chi Hang Lui, Hiroo Uchida, Gail E. Besner, Ronald B. Hirschl, Jianghua Zhan, Jiexiong Feng

HepatoBiliary Surgery and Nutrition

2026;

(4)

:103

(01 August 2026)

PDF Full Text (28) Reporting Checklist Peer Review File COI Form Open Access

This consensus summarizes the latest literature on BA and brings together 23 opinions and recommendations from 50 experts from both East and West. International guidelines for BA can provide guidance on current practice for surgeons, patients, medical societies, hospital administrators, and relevant community groups.

French Editorial Commentary from the ACHBPT

Liver transplantation changes the rules for colorectal liver metastases

Diana Berzan, Stylianos Tzedakis, Heithem Jeddou

HepatoBiliary Surgery and Nutrition

2026;

(4)

:104

(01 August 2026)

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Total pancreatectomy friend or foe?

Emmanuel Devant, Mircea Chirica

HepatoBiliary Surgery and Nutrition

2026;

(4)

:105

(01 August 2026)

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Editorial Commentary

Postoperative hyperamylasemia—an early warning signal after distal pancreatectomy

Bernhard W. Renz, Jens Werner

HepatoBiliary Surgery and Nutrition

2026;

(4)

:106

(01 August 2026)

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Precision of computed tomography volumetry in living donor liver transplantation: current evidence, limitations, and future directions

Yu Saito, Yuji Morine, Shinichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Tetsuya Ikemoto

HepatoBiliary Surgery and Nutrition

2026;

(4)

:107

(01 August 2026)

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Sexual dimorphism in liver cancer recurrence: the role of SRY and ischemia-reperfusion injury

Ranish K. Patel, Skye C. Mayo

HepatoBiliary Surgery and Nutrition

2026;

(4)

:108

(01 August 2026)

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Hepatitis B virus-specific T cell receptor therapy for advanced hepatocellular carcinoma: lessons from Wu et al.

Rashmi Kumar, Irina Dobrosotskaya, Timothy L. Frankel

HepatoBiliary Surgery and Nutrition

2026;

(4)

:109

(01 August 2026)

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The era of minimally invasive pancreatic surgery: is the robot ready to replace laparoscopy for extended left pancreatectomy?

Kai Siang Chan, Vishal G. Shelat

HepatoBiliary Surgery and Nutrition

2026;

(4)

:110

(01 August 2026)

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Are we ready for a molecular diagnostics-driven era in hepatobiliary surgery?

Zi-Jie Tang, Jia-Hao Xu, Li-Hui Gu, Xin Li, Tian Yang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:111

(01 August 2026)

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Dual TIGIT and PD-1 blockade in immunotherapy-refractory hepatocellular carcinoma: a signal beyond resistance?

Maria Stella Franzè, Giuliana Amaddeo

HepatoBiliary Surgery and Nutrition

2026;

(4)

:112

(01 August 2026)

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DGAT2 inhibition in MASH: histologic promise and lipid paradox

Sarpong Boateng, Chloe Bennett, Reda M. Al Badawy, Thiruvengadam Muniraj

HepatoBiliary Surgery and Nutrition

2026;

(4)

:113

(01 August 2026)

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Surgical data extractivism: the false promise of institutional custodianship

Yu-Han Cui, Jia-Qi Du, Guo-Wei Wang, Zi-Jie Tang, Tian Yang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:114

(01 August 2026)

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Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge to overcome digestive malignancies

Congcong Zhang, Junjing Yang, Xia Xiao, Weiming Yu, Xianlei Cai

HepatoBiliary Surgery and Nutrition

2026;

(4)

:115

(01 August 2026)

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Protein S-sulfhydration: an emerging regulatory layer with therapeutic potential in metabolic dysfunction-associated steatotic liver disease

Mingchang Pang, Huayu Yang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:116

(01 August 2026)

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From local control to immune synergy: the evolving role of stereotactic body radiotherapy in the immunotherapy era of hepatocellular carcinoma

Zihan Yan, Xiaorong Hou, Fuquan Zhang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:117

(01 August 2026)

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3D bioprinting in liver transplantation: from organ replacement to transplantable functional support

Kai Zhang, Shunda Du

HepatoBiliary Surgery and Nutrition

2026;

(4)

:118

(01 August 2026)

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Editorial

Evolution of minimally invasive surgery in gallbladder carcinoma: maintaining oncological radicality and the enduring value of open resection

Tomoyuki Abe, Shintaro Kuroda, Tsuyoshi Kobayashi, Hideki Ohdan

HepatoBiliary Surgery and Nutrition

2026;

(4)

:119

(01 August 2026)

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Letter to the Editor

Eggplant-like pancreas: transformation in a year

Jia Li, Songling Liu, Shihao Jiang, Yuansong He, Chao Chen, Wei Cheng, Lei Zhou

HepatoBiliary Surgery and Nutrition

2026;

(4)

:120

(01 August 2026)

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Significant portal hypertension: porto-sinusoidal vascular disease associated with atypical Adams-Oliver syndrome

Yi Song, Huabao Liu, Wenyan Hu, Ying Wan, Yi Huang, Chunyan Rao

HepatoBiliary Surgery and Nutrition

2026;

(4)

:121

(01 August 2026)

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Lack of blood may drive liver neoplasm: a case of an intrahepatic portosystemic venous shunt and liver focal nodular hyperplasia with elevation of serum PIVKA-II level

Yunhan Mao, Han Zheng, Xueshuai Wan, Yiyao Xu, Shunda Du

HepatoBiliary Surgery and Nutrition

2026;

(4)

:122

(01 August 2026)

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Pediatric ex-vivo liver resection and auto-transplantation for complex hepatic alveolar echinococcosis

Yucheng Hou, Di Wu, Dong Feng, Lihan Yu, Hongqiang Zhao, Guangdong Wu, Xueqing Li, Rui Tang, Qian Lu

HepatoBiliary Surgery and Nutrition

2026;

(4)

:123

(01 August 2026)

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From associations to action: deepening the clinical and mechanistic implications of obesity indices in T2DM risk stratification

Yuan Yang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:124

(01 August 2026)

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Obesity indices and type 2 diabetes risk: implications for dynamic assessment and metabolic mechanisms

Bo Wu, Yun Chen, Haitao Xu, Qi Zhao, Yue Chen, Xiaolian Dong, Chaowei Fu

HepatoBiliary Surgery and Nutrition

2026;

(4)

:125

(01 August 2026)

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Viewpoint

Beyond the H-index: re-centering the operating room in the evaluation of the surgeon-scientist in hepatobiliary surgery

Agostino Maria De Rose

HepatoBiliary Surgery and Nutrition

2026;

(4)

:126

(01 August 2026)

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Images in Clinical Medicine

Massive hepatic hemangioma complicated by Kasabach-Merritt syndrome

Xixi Gao, Jia Huang, Zhiying Yang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:127

(01 August 2026)

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Diaphragmatic hernia following right hemihepatectomy

Yuxiao Sun, Lei Zhang

HepatoBiliary Surgery and Nutrition

2026;

(4)

:128

(01 August 2026)

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Review Article

Hilar cholangiocarcinoma: diagnosis, treatment options, and management

Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Published online: 28 February 2014

PDF Full Text (35664) Open Access

Review Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction

Metin Basaranoglu, Gokcen Basaranoglu, Elisabetta Bugianesi

Published online: 17 April 2015

PDF Full Text (35619) Open Access

Review Article

Updates in Mirizzi syndrome

Alan Isaac Valderrama-Treviño, Juan José Granados-Romero, Mariana Espejel-Deloiza, Jonathan Chernitzky-Camaño, Baltazar Barrera Mera, Aranza Guadalupe Estrada-Mata, Jesús Carlos Ceballos-Villalva, Jonathan Acuña Campos, Rubén Argüero-Sánchez

Published online: 07 June 2017

PDF Full Text (34227) Open Access

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings

Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis

Published online: 31 August 2013

PDF Full Text (32304) Open Access

Review Articles on Liver Immunology: Part 1

Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology

Ralf Weiskirchen, Frank Tacke

Published online: 19 December 2014

PDF Full Text (31142) Open Access

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Post-hepatectomy liver failure

Rondi Kauffmann, Yuman Fong

Published online: 01 October 2014

PDF Full Text (26983) Open Access

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The multifaceted nature of retinoid transport and metabolism

Yang Li, Nuttaporn Wongsiriroj, William S. Blaner

Published online: 27 June 2014

PDF Full Text (24201) Open Access

Review Article

Techniques for prevention of pancreatic leak after pancreatectomy

Hans F. Schoellhammer, Yuman Fong, Singh Gagandeep

Published online: 01 October 2014

PDF Full Text (23236) Open Access

Review Articles on Liver Immunology: Part 1

Immune mechanisms in acetaminophen-induced acute liver failure

Oliver Krenkel, Jana C. Mossanen, Frank Tacke

Published online: 19 December 2014

PDF Full Text (21245) Open Access

Review Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Fatty liver disease in diabetes mellitus

Harikrashna B. Bhatt, Robert J. Smith

Published online: 17 April 2015

PDF Full Text (21155) Open Access

Review Articles on Liver Immunology: Part 1

Immunomodulatory effects of transforming growth factor-β in the liver

Hans-Theo Schon, Ralf Weiskirchen

Published online: 19 December 2014

PDF Full Text (21017) Open Access

Review Article on Intrahepatic Cholangiocarcinoma

Management of unresectable intrahepatic cholangiocarcinoma: how do we decide among the various liver-directed treatments?

Eugene J. Koay, Bruno C. Odisio, Milind Javle, Jean-Nicolas Vauthey, Christopher H. Crane

Published online: 15 April 2017

PDF Full Text (19410) Open Access

Review Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Sirtuin 1 signaling and alcoholic fatty liver disease

Min You, Alvin Jogasuria, Charles Taylor, Jiashin Wu

Published online: 17 April 2015

PDF Full Text (18953) Open Access

Editorial

Cystic liver lesions: from diagnosis to recognition of complications and when to treat

Sarah Lowry, Wikrom Karnsakul

Published online: 01 December 2022

PDF Full Text (18835) COI Form Open Access

Review Article

Small for size liver remnant following resection: prevention and management

Rony Eshkenazy, Yael Dreznik, Eylon Lahat, Barak Bar Zakai, Alex Zendel, Arie Ariche

Published online: 01 October 2014

PDF Full Text (17810) Open Access

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Correlation between 3D-MRCP and intra-operative findings in right liver donors

Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa

Published online: 17 December 2012

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Complications after percutaneous ablation of liver tumors: a systematic review

Eylon Lahat, Rony Eshkenazy, Alex Zendel, Barak Bar Zakai, Mayan Maor, Yael Dreznik, Arie Ariche

Published online: 01 October 2014

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Therapeutic targeting of liver inflammation and fibrosis by nanomedicine

Matthias Bartneck, Klaudia Theresa Warzecha, Frank Tacke

Published online: 19 December 2014

PDF Full Text (17575) Open Access

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Cholangiocarcinoma: increasing burden of classifications

Vincenzo Cardinale, Maria Consiglia Bragazzi, Guido Carpino, Alessia Torrice, Alice Fraveto, Raffaele Gentile, Vincenzo Pasqualino, Fabio Melandro, Camilla Aliberti, Carlo Bastianelli, Roberto Brunelli, Pasquale Bartolomeo Berloco, Eugenio Gaudio, Domenico Alvaro

Published online: 31 October 2013

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Gallbladder cancer

Mislav Rakic, Leonardo Patrlj, Mario Kopljar, Robert Klicek, Marijan Kolovrat, Bozo Loncar, Zeljko Busic

Published online: 01 October 2014

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Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes

Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

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Melatonin regulation of biliary functions

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Risk stratification for Hepatitis B treatment in the molecular age

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Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats

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Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions

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Contribution of bone marrow-derived fibrocytes to liver fibrosis

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Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice

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DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis

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Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux

Mary Kelly, Johannes von Lintig

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Alcohol exposure in utero perturbs retinoid homeostasis in adult rats

Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

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The GOLP regimen: pushing the boundaries of conversion therapy in locally advanced biliary tract cancer

Takeshi Okamoto

Published online: 03 August 2026

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When a suspicious liver lesion is not cancer: primary hepatic myopericytoma in chronic hepatitis B

Xiao Liu, Xiaokun Chen, Xiaoyan Chang, Shunda Du

Published online: 24 July 2026

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Overcoming immune exclusion in intrahepatic cholangiocarcinoma: mechanistic insights from the CASTLE‑01 trial

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Published online: 24 July 2026

Original Article

Development and Validation of a Race- and Ethnicity-Adjusted Index for Metabolic Dysfunction-associated Steatotic Liver Disease

Xinyuan He, Zhiluo Yang, Takanori Ito, Zhanpeng Yang, Hideyuki Hyogo, Masafumi Ono, Kentaro Oniki, Tetsuhito Kojima, Zixuan Xing, Yi Liu, Meijuan Han, Yuan Wang, Naoyoshi Kariya, Shinya Yokoyama, Xinrong Zhang, Jian Zu, Ming-Hua Zheng, Junji Saruwatari, Hirokazu Takahashi, Yee Hui Yeo, Lei Zhang, Takashi Honda, Mindie H. Nguyen, Fanpu Ji

Published online: 17 July 2026

Letter to the Editor

Microwave Ablation-Assisted Laparoscopic Partial Splenectomy with Multi-Angle Layered Ablation

Wenliang Tan, Jinxing Wei, Chuchu Tan, Yajin Chen, Changzhen Shang

Published online: 17 July 2026

Letter to the Editor

Emergency Remote Robotic Right Hepatectomy for Spontaneous Rupture of Hepatocellular Carcinoma

Fengwei Gao, Zhigui Li, Xin Zhao, Qingyun Xie, Zongtao Song, Bingran Zhang, Xiang Zhu, Zhenghao Su, Danzeng Laba, Taqing Suoba, Xiaoou Li, Wei Yuan, Jun Ma, Mengsong Wang, Tian Lan, Yaowen Jiang, Nian Li, Yunshi Cai, Jiayin Yang, Hong Wu

Published online: 17 July 2026

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Microbiome research in liver transplantation

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Published online: 16 July 2026

Original Article

The Immunosuppressive Tumor Microenvironment and Mechanisms of Tumor Recurrence After Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS)

Zhifeng Jiang, Runze Miao, Yang Xu, Jiaxi Zhu, Shiyu Zhang, Senquan Zhang, Jiayan Yan, Feiyu Chen, Ao Huang, Jian Zhou

Published online: 08 July 2026

Original Article

Prediction of HCC recurrence with liver and tumor stiffness measured by MR elastography – a systematic review and meta-analysis

Agnes K. Boehm, Felix Strobl, Theresa Keller, Anna Speth, Felix Krenzien, Wenzel Schöning, Johann Pratschke, Ingolf Sack, Igor M. Sauer, Philipp K. Haber, Karl H. Hillebrandt

Published online: 08 July 2026

Original Article

Use of Glucagon-Like Peptide 1 Receptor Agonists and Risk of MASLD in Overweight or Obese Adults with Type 2 Diabetes Mellitus: A Target Trial Emulation Study

Xianhua Mao, Xinrong Zhang, Linda Henry, Ka-Shing Cheung, Man-Fung Yuen, Ramsey Cheung, Mindie H Nguyen

Published online: 08 July 2026

Images in Clinical Medicine

The Hidden Culprit: Mesenteric Venous Occlusion Presenting as Refractory Upper Gastrointestinal Bleeding Post‑Whipple

Mucong Li, Yingfan Li, Fengdan Wang, Tao Guo, Menghua Dai, Gechong Ruan, Hong Yang

Published online: 08 July 2026

Original Article

Artificial intelligence literacy, attitudes, and use among surgical educators in China: a nation wide, cross-sectional study

Chen Lin, Nasu Wang, Zhen Cao, Tianyu Li, Georgios Antonios Margonis, Jaeyun Jane Wang, Jiashu Han, Yixuan Sun, Ning Lu, Liangbo Dong, Yaozong Wang, Shuai Xiao, Bo Li, Zhigang Wei, Jinhong Chen, Dongming Zhang, Weidong Xiao, Tuerganaili Aji, Basangdunzhu, Feng Wang, Weibin Wang

Published online: 01 July 2026

Original Article

Global treatment rate and impact of direct-acting antiviral on clinical outcomes in HCV-related hepatocellular carcinoma: a systematic review and meta-analysis

Taotao Yan, Takanori Ito, Tsukasa Yasuda, Takaya Suzuki, Michael H. Le, Rui Huang, Yu Shi, Haruki Uojima, Vy H. Nguyen, Xiangrong Gao, Zhiwen Fan, Ramsey Cheung, Mindie H. Nguyen

Published online: 29 June 2026

Original Article

Postoperative outcomes after neoadjuvant therapy followed by resection versus upfront resection in MDT-defined borderline resectable hepatocellular carcinoma: a propensity score-matched analysis of patients who underwent resection

Xingfei Li, Delin Ma, Tao Li, Zhao Li, Tantu Ma, Yang Wang, Tong Zhou, Jiye Zhu, Jie Gao

Published online: 29 June 2026

Original Article

Prediction of clinically relevant postoperative pancreatic fistula after pancreatic surgery using MR elastography–a systematic review and meta-analysis

Agnes K. Boehm, Ingolf Sack, Theresa Keller, Eriselda Keshi, Matthäus Felsenstein, Michael J. Pflüger, Timo A. Auer, Uli Fehrenbach, Johann Pratschke, Igor M. Sauer, Thomas Malinka, Karl H. Hillebrandt

Published online: 25 June 2026

Letter to the Editor

Photon-counting CT-guided precise subtotal resection of pancreatic head benign tumor with complete protection of pancreaticoduodenal arcades

Jiashu Han, Mengwei Wu, Jingyi Liu, Liang Zhu, Weibin Wang, Chen Lin

Published online: 25 June 2026

Review Article

Sequencing-based biomarker discovery in liver transplantation: a narrative review

Sabrina Stimmeder, Adam M. Thorne, Ton Lisman, Vincent E. de Meijer

Published online: 25 June 2026

Letter to the Editor

Two Grafts, One Implant: Ex Vivo Assembly and En Bloc Piggyback Implantation for Dual-graft Liver Transplantation

Xi Xu, Chen Jin, Yiliyaer Aierken, Jiulin Song, Tong Chen, Wei Gao, Youlong Wu, Feihong Weng, Shouping Wang, Jian Yang, Tao Lv, Gang Xu, Jiayin Yang

Published online: 25 June 2026

Original Article

Perioperative Glucose Variability and Hypoglycemic Burden Are Associated with Clinically Relevant Pancreatic Fistula: A Multicenter Prospective Cohort Study

Le Zhang, Ling Lan, Xianlin Han, Yuelun Zhang, Weibin Wang, Le Shen, Yuguang Huang; the CGM–Pancreatic Surgery Collaborative Group

Published online: 25 June 2026

Editorial Commentary

Mechanical Hypertrophy versus Biological Optimization: Rethinking the Role of ALPPS in the Era of Systemic Therapy

Yu-Han Cui, Guo-Qing Zhang, Xin Liang, Zu-Chao Du, Jia-Hao Xu, Li-Hui Gu, Ming-Da Wang, Chao Li, Tian Yang

Published online: 25 June 2026

Original Article

Transumbilical Venous Inflow for in Situ Hypothermic Perfusion without Venovenous Bypass During Complex Hepatectomy: Comparison with Portal Vein Cannulation

Xinyu You, Hongming Xing, Bangyou Zuo, Donghui Cheng, Jianhua Huang, Chong Yang, Jipeng Jiang, Peng Li, Pan He, Yu Zhang

Published online: 25 June 2026

Original Article

Association of GLP-1RA and/or SGLT2i treatment with lower risk of adverse clinical outcomes among patients with MASLD: a systematic review and meta-analysis

Jie Wang, Taotao Yan, Haruki Uojima, Xiangrong Gao, Michael H Le, Zhiwen Fan, Kylie Rosenberg, Jake Israni, Xianhua Mao, Evans M. Whittaker, Ramsey Cheung, Mindie H. Nguyen

Published online: 25 June 2026

Original Article

Continuous adjuvant therapy with the same regimen improves survival following conversion therapy and hepatectomy in initially unresectable hepatocellular carcinoma: a multicenter retrospective study

Zhenyun Yang, Xiaohui Wang, Houping Zhou, Xiaoxian Sima, Wei Peng, Juncheng Wang, Dandan Hu, Zhongguo Zhou, Minshan Chen, Huilan Zeng, Yaojun Zhang, Yizhen Fu

Published online: 25 June 2026

Original Article

Assessing Synthetic and Cholestatic Function for Decompensation and Mortality in Compensated Cirrhosis. The CORE Consortium

David Shengyang Zhang, Margaret Li Peng Teng, Nicole Shu Ying Tang, Vincent L Chen, Jimmy Che-To Lai, Karn Wijarnpreecha, Rahul Kumar, Apichat Kaewdech, Thanawin Pramotedham, Anand V Kulkarni, Ming-Hua Zheng, Akash Roy, Ken Liu, Chitchai Rattananukrom, Mazen Noureddin, Mohammad Shadab Siddiqui, Mark D Muthiah, Cheng Han Ng, Hirokazu Takahashi; the CORE Consortium

Published online: 25 June 2026

Original Article

Prognostic Impact of Background Hepatic Steatosis on Outcomes After Curative Resection for Hepatocellular Carcinoma: A Propensity Score–Matched Cohort Study

Dong Li, Yang Huang, Litian Zhang, Jiawu Yan, Liangliang Xu, Mingqing Xu, Li Jiang

Published online: 25 June 2026

Original Article

Optimized Subharmonic-aided Portal Vein Pressure Estimation via Microbubble Sensors

Mingchang Pang, Huimin Lu, Gang Xu, Laixin Huang, Yonghao Wen, Yun Wang, Lingling Li, Deyu Li, Huayu Yang, Fei Li, Yilei Mao

Published online: 25 June 2026

Original Article

Long-term survival of laparoscopic vs. open hepatectomy for subcapsular hepatocellular carcinoma: A Propensity Score-Matched Analysis

Qingyan Kong, Chuan Li, Jiahui Yang, Diao Kong, Zheyu Chen, Wei Peng

Published online: 25 June 2026

Review Article

Preoperative Biliary Drainage in Resectable Perihilar Cholangiocarcinoma: Why, When, and How—A Narrative Review

Noa Toussaint, Arthur Marichez, Medhi Boubaddi, Clément Subtil, Bruno Lapuyade, Laurence Chiche

Published online: 12 June 2026

Original Article

Post-transplant MASLD does not adversely affect long-term survival or cardiometabolic outcomes following liver transplantation

Suk Min Gwon, Goeun Park, Jongman Kim, Jiyoung Baik, Hayeon Do, Namkee Oh, Jinsoo Rhu, Wonseok Kang, Woo Kyoung Jeong, Kyunga Kim, Gyu Seong Choi, Jae Won Joh

Published online: 11 June 2026

Expert Consensus

Chinese guidelines for perioperative whole-course nutrition management in pancreatic surgery (2025 edition)

Jingyong Xu, Rongrong Li, Hui Zhang, Jin Gu, Yongsu Ma, Yucheng Zhou, Lijuan Wang, Xianna Zhang, Yu Fang, Hao Wu, Jinhui Hou, Weijing Li, Ping Zeng, Bin Zhang, Xinying Wang, Wei Chen, Mingwei Zhu, Wenming Wu, Yinmo Yang, Hua Yang, Arved Weimann, Huanlong Qin, Yupei Zhao, Junmin Wei, the Chinese Society for Parenteral and Enteral Nutrition, the Pancreatic Surgery Group of the Chinese Society of Surgery

Published online: 11 June 2026

Letter to the Editor

Sclerosing epithelioid mesenchymal neoplasm of the pancreas: a rare mimicker of common pancreatic neoplasms

Shengwei Mo, Boju Pan

Published online: 10 June 2026

Original Article

Total neoadjuvant therapy as a perioperative strategy for pancreatic ductal adenocarcinoma: a systematic review and meta-analysis

Lelang Xiang, Yi Jin, Ran Hu, Yuhang He, Keyu Li, Ang Li

Published online: 08 June 2026

Review Article

Omics-driven biomarker discovery for immune checkpoint inhibitor-based therapy in biliary tract cancer: a narrative review

Yuejun Liu, Zixiang Zhou, Ziyu Xun, Boyu Sun, Binhe Tian, Ze Zhou, Xiangqi Chen, Nan Zhang, Mingjian Piao, Shuofeng Li, Chengjie Li, Jiongyuan Li, Zhaohui Li, Yihong Zhang, Yao Zhao, Haitao Zhao, Hanping Wang

Published online: 05 June 2026

Original Article

Validation of the Institute Mutualiste Montsouris (IMM) system for the stratification of robotic liver resections: an international multicenter study

Qu Liu, Hwee-Leong Tan, Nicholas L. Syn, Gabriela Pilz da Cunha, Moritz Schmelzle, Jason Hawksworth, Umberto Cillo, Atsushi Sugioka, Yutaro Kato, David Fuks, Olivier Soubrane, Paulo Herman, Yonggang Wei, Marco V. Marino, Roland S. Croner, Olivier Scatton, Adrian K. H. Chiow, Sung-Hoon Choi, Jae Hoon Lee, Marco Vivarelli, Federico Mocchegiani, Felice Giuliante, Andrea Ruzzenente, Mengqiu Yin, Paolo Magistri, Fabrizio Di Benedetto, David Geller, Andrea Belli, Riccardo Memeo, Kristin Goodsell, James O. Park, Victor Lopez-Lopez, Ricardo Robles-Campos, Robert P. Sutcliffe, Felix Krenzien, Alesandro Ferrero, Giuseppe Maria Ettorre, Junhao Zheng, Xiao Liang, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Ho-Seong Han, Bjorn Edwin, Kuo-Hsin Chen, Mohammad Abu Hilal, Luca Aldrighetti, Mikhail Efanov, Wanguang Zhang, Emanuele F. Kauffmann, Ugo Boggi, Raffaele Brustia, Mathieu D’Hondt, Xiaoying Wang, Alejandro Mejia, Gi-Hong Choi, Charing C. N. Chong, Rutger-Jan Swijnenburg, T. Peter Kingham, Johann Pratschke, Eric C. H. Lai, Chung-Ngai Tang, Iswanto Sucandy, Rong Liu, Brian K. P. Goh; International Robotic and Laparoscopic Liver Resection Study Group Investigators

Published online: 02 June 2026

Review Article

Prioritising preventive approaches for metabolic dysfunction-associated steatohepatitis in high-risk populations: a narrative review

Mohammad Shafi Kuchay, Fernando Bril, Camilo Julio Llamoza-Torres, Scott Isaacs, Bruno Ramos-Molina

Published online: 20 May 2026

Original Article

Predictors of Textbook Outcomes in Liver Resection with Vascular Reconstruction: An International Multicenter Study

Victor Lopez-Lopez, Christoph Kuemmerli, Cecilia Maina, Francesca Ratti, Juan Gonzalez-Ferez, Sarah Daniels, Nikhil Suresh, Augustin Suffisseu, Safi Dokmak, Elias Karam, Yawen Dong, Zhihao Li, Rory L. Smoot, Muhammad Ahmad Nadeem, Federico Aucejo, Emilio Vicente, Enrico Gringeri, Eleonora Nieddu, Jordi Navinés-López, Lucia Hernandez-Ramos, Mohammad H Fard-Aghaie, Jens Rolinger, Leyre Serrablo, Dilmurodjon Eshmuminov, Sanjay Govil, William Archie, Dionisios Vrochides, Martin de Santibañes, Eduardo de Santibañes, Fabrizio Di Benedetto, Silvio M P Balzan, Cristina Dopazo, Vicente Borrego-Estella, Giuseppe Kito Fusai, Fernando Rotellar-Sastre, Roberto I Troisi, Alejandro Serrablo, Silvio Nadalin, Karl J Oldhafer, Esteban Cugat, Umberto Cillo, Andrea Schlegel, Patrick Starlinger, Mickael Lesurtel, Pierre Alain Clavien, Daniel Azoulay, Jose Manuel Ramia, Peter Lodge, Ricardo Robles Campos

Published online: 19 May 2026

Original Article

Concurrent loco-regional therapy associated with improved survival in non-virus-related unresectable hepatocellular carcinoma who received systemic therapies: a multi-center retrospective cohort study (CLEAP-2502)

Yangxun Pan, Jianfeng Zhang, Hongzhi Liu, Xiaodong Zhu, Shunli Shen, Kui Wang, Huichuan Sun, Wei Zhang, Li Xu; China Liver Cancer Study Group Young Investigators (CLEAP)

Published online: 19 May 2026

Original Article

Genotype–Phenotype Associations Underlying Very Early Recurrence After Intrahepatic Cholangiocarcinoma Resection

Kizuki Yuza, Jun Kawashima, Miho Akabane, Yutaka Endo, Odysseas P Chatzipanagiotou, Christian Hobeika, Federico Aucejo, Hugo P. Marques, Tom Hugh, Feng Shen, Shishir K. Maithel, Bas Groot Koerkamp, Irinel Popescu, Minoru Kitago, Matthew J. Weiss, Guillaume Martel, Carlo Pulitano, George Poultsides, Andrea Ruzzente, Todd W. Bauer, Ana Gleisner, Itaru Endo, Timothy M. Pawlik

Published online: 15 May 2026

Letter to the Editor

Selected heavy-drinking donor livers may be safe, but important questions remain

Cheng-Wei Lu

Published online: 15 May 2026

Original Article

Preoperative prediction of microvascular invasion in hepatocellular carcinoma: an umbrella review of systematic reviews and meta-analyses with etiology-specific implications

Seoung Hoon Kim, Byeong Ho An, Jin A. Lee, Go Woon Jeong

Published online: 15 May 2026

Original Article

Textbook outcome after robotic vs. laparoscopic hepatectomy: a secondary post-hoc analysis of the randomized ROC‘N’ROLL trial

Emrullah Birgin, Marie Heibel, Svetlana Hetjens, Erik Rasbach, Christoph Reissfelder, Patrick Téoule, Nuh N. Rahbari

Published online: 30 April 2026

Review Article

Endoscopic management of post-surgical biliary complications in liver transplant patients—a narrative review

Mira Xhuveli, Angelo Bruni, Margherita Prior, Giulia Di Noia, Douglas Thorburn, Matteo Cescon, Rocco Maurizio Zagari, Matteo Serenari, Leonardo Henry Eusebi

Published online: 30 April 2026

Original Article

Local interventions improve survival of hepatocellular carcinoma patients with brain metastases in the era of targeted and immune‐based therapies: a single‐center retrospective cohort study

Qian-Qian Zhao, Yan-Yan Lin, Huan-Liang Chen, Pan Zhou, Jiao-Yang Yang, Zhao-Chong Zeng

Published online: 30 April 2026

Original Article

Surgical management of choledochal cysts over three decades: a single-center experience focusing on type IVa and V

Hala Muaddi, Yawen Dong, David Pereyra, Vanja Podrascanin, Jonas Santol, Markus Ammann, Rory L. Smoot, David M. Nagorney, Patrick P. Starlinger

Published online: 30 April 2026

Original Article

A single-center experience establishing an adult living donor robotic hepatectomy program for liver transplantation in North America: a retrospective cohort review of the first 50 cases

Andrew Jacques, Suzie Seung Hee Lee, Eric Martinez, Johanna Bayer, Juan Sebastian Danobeitia, Giuliano Testa, Amar Gupta

Published online: 29 April 2026

Clinical Practice Guideline

Chinese clinical guidelines for the diagnosis and treatment of sarcopenia in liver transplant recipients

Di Lu, Jianyong Zhuo, Zuyuan Lin, Hualian Hang, Zhikun Liu, Guanghan Fan, Li Zhuang, Tian Shen, Hengkai Zhu, Huigang Li, Yuhang Li, Xiao Xu; Liver Transplantation Group, Branch of Organ Transplantation of Chinese Medical Association; Branch of Organ Transplant Physicians of Chinese Medical Doctor Association

Published online: 29 April 2026

Review Article

Therapeutic advances in hepatocellular carcinoma with portal vein tumor thrombus in the era of immuno-targeted therapy—a narrative review

Zhenli Li, Liang Li, Yibing Zhang, Shuaishuai Zhu, Yuanzhi Ni, Lindi Xu, Shixing Yan, Shuqun Cheng, Yufu Tang

Published online: 28 April 2026

Original Article

Laparoscopic vs. open liver resection for hepatocellular carcinoma: systematic review and meta-analysis based on the Third International Consensus Conference on Minimally Invasive Liver Resection

Ahmed Shehta, Ho-Seong Han, Mohamed A. Alsaied, Maab M. Saleh, Mohamed R. Saad, Mai M. Rizk, Boram Lee, Hae-Won Lee, Jai Young Cho

Published online: 28 April 2026

Original Article

An albumin-bilirubin-based multivariable model for fairly predicting perioperative mortality after liver transplantation in the modern era

Yixian Huang, Bi Pan, Xiaoyi Fan, Tao Lv, Jian Yang, Kunlin Xie, JiuLin Song, Lingxiang Kong, Jingsheng Yuan, Xi Xu, Chen Jin, Chengcheng Zhang, Yuancheng Li, Hongji Yang, Xingchao Liu, Zhu Li, Shaohua Song, Zhengxin Wang, Yifeng Tao, Yi Zhang, Leida Zhang, Gang Xu, Lvnan Yan, Hong Wu, Jiayin Yang

Published online: 26 April 2026

Original Article

Distinguishing microvascular invasion and satellite nodules: correlation with outcomes after hepatectomy for hepatocellular carcinoma

Zhen-Qi Li, Ze-Tao Yu, Tian-Chen Zhang, Yu Cao, Ming-Gen Hu, Han Wang, Nian-Xin Xia, Wen-Chao Zhao, Xiong Chen, Shuai Xu, Guang Tan, Chao Lin, Tao Jiang, Yun-Fei Xu, Fan Zhang, Zhong-Hua Liu, Hong-Xing Jiang, Qing-Qiang Ni, Yu-Fu Tang, Yi-Lin Hu, Yi-Meng Lu, Yi-Ren Hu, Kai Wang, Zhi-Qiang Wang, Rui-Fang Fan, Jian-Hua Lin, Mao-Lin Yan, Xiao-Dong Tan, Shu-Qun Cheng, Xiu-Ping Zhang, Rong Liu

Published online: 25 April 2026

Original Article

Optimal timing of cholecystectomy after necrotizing biliary pancreatitis: a multi-institutional propensity-matched study

Rahul Karna, Himsikhar Khataniar, Hany Habib, Stuart K. Amateau

Published online: 24 April 2026

Original Article

Lenvatinib plus PD-1 inhibitors with transarterial embolization and hepatic arterial infusion chemotherapy for unresectable hepatocellular carcinoma: a bias-adjusted survival and clinical trajectory analysis

Lixin Du, Yang Zhang, Weiwei Lv, Hui Zhang, Tiezhong Zhang, Kangshuai Li, Qiangbo Zhang, Ben Wang, Dong Sun, Chunxiao Hu, Runde Jiang, Chuanzong Zhao, Hao Chen, Yi Liu, Yunfei Xu, Guangzhen Li, Sen Guo, Zongli Zhang

Published online: 23 April 2026

Original Article

Adjuvant chemoimmunotherapy vs. capecitabine vs. observation in resected biliary tract cancer: a multi-center retrospective study

Chengjie Li, Mingjian Piao, Zibo Xu, Weixuan Pan, Shuman Kuang, Ziyue Huang, Nan Zhang, Jiongyuan Li, Shuofeng Li, Guanhua Yu, Shi Feng, Hu Li, Zhe Zhu, Binhe Tian, Xiaobo Yang, Chengpei Zhu, Daobing Zeng, Zhenyu Zhu, Yongliang Sun, Weidong Duan, Haitao Zhao

Published online: 23 April 2026

Original Article

Impact of expert centers annual case volume on outcomes of minimally-invasive liver resections: international multicenter study

Federica Cipriani, Francesca Ratti, Nicholas L. Syn, Ken-Min Chin, Qu Liu, Wanguang Zhang, Giuseppe Zimmitti, Davit L. Aghayan, Tiing-Foong Siow, Olivier Scatton, Paulo Herman, Safi Dokmak, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung-Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Zewei Chen, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Kiyoshi Hasegawa, Roland S. Croner, Salvatore Gruttadauria, Jason Hawksworth, James O. Park, Fernando Rotellar, Gi-Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Chung-Ngai Tang, Charing C. N. Chong, Mathieu D’Hondt, Kazuteru Monden, Santiago Lopez-Ben, T. Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Rutger-Jan Swijnenburg, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Motokazu Sugimoto, Tran Cong Duy Long, Yufu Peng, Yonggang Wei, Kuo-Hsin Chen, Olivier Soubrane, David Fuks, Rong Liu, Ho-Seong Han, Mohammad Abu Hilal, Bjørn Edwin, Brian K. P. Goh; International Robotic and Laparoscopic Liver Resection Study Group Investigators

Published online: 16 April 2026

Original Article

Nutritional recovery and physical activity after pancreaticoduodenectomy are poor: lessons learned from an observational pilot study

Mary E. Phillips, Rajesh Kumar, David B. Bartlett, Nariman D. Karanjia, Kathryn H. Hart, Adam E. Frampton

Published online: 07 April 2026

Original Article

Applicability and effectiveness of a formula-based low-carb diet in metabolic dysfunction-associated steatotic liver disease—a single-arm interventional study

Philipp Hruska, Georg Semmler, Manuela Teufelhart, Harald Hofer, Robert Winker, Benedikt Mehl, Christian Rabitsch, Bernadette Barta, Peter Ferenci, Helmuth Haslacher, Michael Trauner, Thomas-Matthias Scherzer

Published online: 27 March 2026

Original Article

Global burden of primary liver cancer: a global modelling study from 1990 to 2021 with projections to 2050

Xinrong Zhang, Charles R. Levesley, Sovann Linden, Tyler Wong, Scott Barnet, Ramsey Cheung, Fanpu Ji, Mindie H. Nguyen

Published online: 24 March 2026

Original Article

Inhibition of ferroptosis by propofol injectable emulsion protects hepatocytes against ischemia/reperfusion injury

Chen Sun, Pan Liu, Mengyun Zhao, Yuguang Huang, Lijian Pei

Published online: 24 March 2026

Original Article

Incomplete ablation vs. complete ablation for solitary hepatocellular carcinoma ≤5 cm: the 10-year survival analysis

Mingfang Zhang, Zhoutian Yang, Yangxun Pan, Zili Hu, Deyao Zhang, Teng Long, Zhenyun Yang, Jing Zhao, Jingxian Shen, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Huilan Zeng, Yaojun Zhang, Minshan Chen

Published online: 05 March 2026

Original Article

The burden and forecasts for metabolic dysfunction-associated fatty liver disease among adolescents and young adults in the Arab region

Ziyan Pan, Faisal M. Sanai, Said A. Al-Busafi, Abdulla Al Hassani, Munira Y. Altarrah, Moutaz Derbala, Maheeba Abdulla, Mohamed Tahiri, Nadia Abdelaaty Abdelkader, Nawal Alkhalidi, Bilal Hotayt, Faisal Abaalkhail, Yasser Fouad, Mohammed Eslam

Published online: 05 March 2026

Original Article

Association between bacteriobilia and post-operative complications following pancreaticoduodenectomy—a multi-centre UK cohort study

Luke Taylor, Thomas Sullivan, Karki Bishow, Mihir Milind, Nabeel Merali, Tarak Chouari, Stijn van Laarhoven, Reyad Abbadi, Ayse Demirkan, Philip Williams, Samir Pathak, Adam E. Frampton, James Skipworth

Published online: 26 February 2026

Original Article

Nonalcoholic fatty liver disease promotes early hepatocellular carcinoma recurrence via myeloid-derived suppressor cell metabolic reprogramming: insights from a two-phase recurrence model in mice

Mingming Li, Lei Xu, Shang Yuan, Zhicheng Sun, Qi Su, Zhibin Chang, Lei Zhao

Published online: 26 February 2026

Original Article

Evolution of outcomes after hepatectomy for hepatocellular carcinoma: an analysis of different periods

Chao Li, Ming-Da Wang, Yu-Ze Zhao, Wen-Long Zhai, Yong-Kang Diao, Ya-Hao Zhou, Jun Lu, Ting-Hao Chen, Bo Wu, Hong Wang, Wei-Min Gu, Yong-Yi Zeng, Zi-Jie Tang, Jie Li, Ying-Jian Liang, Hong-Wei Guo, Xin-Fei Xu, Li-Hui Gu, Jia-Hao Xu, Han Wu, Feng Shen, Eric C. H. Lai, Tian Yang; Eastern HepatoBiliary Alliance (EHBA) group

Published online: 26 February 2026

Original Article

Deceased donor liver transplant outcomes: does donor drinking matter?

William A. Preston, Mia Brownfield, Devon J. Pace, Alexandra Cocca, Maya Vasser, Divya Ayyala-Somayajula, Ashesh P. Shah, Adam S. Bodzin

Published online: 25 February 2026

Review Article

The mechanism and implications of PANoptosis in liver diseases: a narrative review

Hui Li, Liang Zhang, Xuewen Xie, Zhifei Chen, Shuke Fei

Published online: 13 February 2026

Original Article

Definition, risk factors, and outcomes of early and late recurrence after curative resection for intrahepatic cholangiocarcinoma

Ye Xu, Qing-Quan Liu, Long Chen, Yu-Hang Ye, Ning Li, Fan Weng, Cun-Yang Tu, Zi-Han Tian, Zheng-Jun Zhou, Jia Fan, Rong-Xin Chen, Jian Zhou, Shao-Lai Zhou

Published online: 06 February 2026

Original Article

Prevalence of surgical site infections following liver transplantation and associated risk factors: a systematic review and meta-analysis

Sarmad Salehi, Pardis Zarepour, Keyvan Karimi, Marjan Sohrabi, Amir Kasraianfard, Ali Jafarian, Akbar Fotouhi

Published online: 29 January 2026

Original Article

Outcomes of extended right hepatectomy (segments I and IV–VIII) after portal vein embolization versus extended liver venous deprivation: a retrospective cohort study from a single center

Evangelia Florou, Mohammad Reza Fattahi, Pauline Kane, Evangelos Prassas, Parthi Srinivasan, Andreas Prachalias

Published online: 29 January 2026

Original Article

Prognostic Nutritional Index helps stratify outcomes of patients with intrahepatic cholangiocarcinoma undergoing curative-intent resection

Takahide Ikeda, Jun Kawashima, Kota Sahara, Miho Akabane, François Cauchy, Federico Aucejo, Hugo P. Marques, Rita Lopes, Andreia Rodriguea, Tom Hugh, Feng Shen, Shishir K. Maithel, Bas Groot Koerkamp, Irinel Popescu, Minoru Kitago, Matthew J. Weiss, Guillaume Martel, Carlo Pulitano, Luca Aldrighetti, George Poultsides, Andrea Ruzzente, Todd W. Bauer, Ana Gleisner, Itaru Endo, Timothy M. Pawlik

Published online: 27 January 2026

Original Article

Associated factors identification and predictive model development for perioperative risk in patients with hepatocellular carcinoma receiving preoperative immunotherapy

Han Li, Peng-Fei Sun, Jun-Yu Long, Hong-Zhi Liu, Qi-Rui Zhang, Zhong-Chao Li, Yong-Yi Zeng, Xin-Yu Bi, Ya-Jin Chen, Zhong Chen, Zhi-Yong Huang, Ming Kuang, De-Yu Li, Xiang-Cheng Li, Xiao Liang, Fu-Bao Liu, Shi-Chun Lu, Tao Peng, Tian-Qiang Song, Hui-Chuan Sun, Kui Wang, Nan-Ya Wang, Tian-Fu Wen, Bao-Cai Xing, Li Xu, Tao Yin, Lei Zhang, Shui-Jun Zhang, Le-Du Zhou, Lei Zhao, Hai-Tao Zhao, Dong-Xu Wang, Tao Li; China Liver Cancer Study Group Young Investigators (CLEAP)

Published online: 21 January 2026

Original Article

Associations between metabolic dysfunction-associated steatotic liver disease and adverse clinical outcomes in chronic kidney disease: a prospective cohort study

Luojia Dai, Zhenqiu Liu, Ming Zhao, Xin Zhang, Chengnan Guo, Shuzhen Zhao, Haili Wang, Jiayi Huang, Chenyu Liang, Tiejun Zhang

Published online: 15 January 2026

Original Article

Modified T category for early-staged intrahepatic cholangiocarcinoma: inclusion of perineural invasion

Tao Wei, Matthew Weiss, Mujtaba Khalil, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lyu, Xu-Feng Zhang, Timothy M. Pawlik

Published online: 14 January 2026

Original Article

Dual radiographic and biochemical response predicts long-term survival benefit of surgery in synchronous liver metastatic pancreatic cancer: a retrospective cohort study

Ruili Wei, Yue Qiu, Yanfen Shi, Yingjixing Luo, Ruyi Liu, Yongliang Sun, Li Xu, Libin Hu, Tianxiao Wang, Jia Huang, Lei Zheng, Zhiying Yang

Published online: 13 January 2026

Original Article

Final results of a phase II trial on the role of intraoperative radiotherapy in reducing local recurrence risk in resectable pancreatic cancer with low-energy X-rays

Jun Hyung Kim, Yeona Cho, Jun Won Kim, Hyung Sun Kim, Ik Jae Lee, Joon Seong Park

Published online: 12 January 2026

Original Article

Long-term outcome of hepatectomy following conversion therapy for initially unresectable hepatocellular carcinoma versus direct hepatectomy for early-stage hepatocellular carcinoma

Xuerui Li, Ze Zhang, Junfeng Li, Wenwen Zhang, Zhe Liu, Tao Wan, Bingyang Hu, Bing Liu, Haowen Tang, Jun Han, Yinzhe Xu, Shichun Lu

Published online: 09 January 2026

Original Article

Robotic versus laparoscopic liver resection for the treatment of hepatocellular carcinoma: an observational study

Chenyue Yang, Junhao Zheng, Yewei Zhang, Meijie Chen, Zefeng Shen, Liye Tao, Shihao Li, Haoyu Pan, Yangyang Xie, Yang Liu, Chao Song, Haijing Guan, Xiao Liang

Published online: 26 December 2025

Review Article

A narrative review on the evolution of outcome reporting in total pancreatectomy with islet autotransplantation

Javed Latif, Cristina Pollard, Ashley Dennison, Giuseppe Garcea

Published online: 23 December 2025

Original Article

Emerging threats of pancreatic diseases in the global workforce: a comprehensive comparative analysis and future projections

Ning Lu, Jiashu Han, Liangbo Dong, Tianyu Li, Yixuan Sun, Nasu Wang, Yaozong Wang, Chen Lin, Weibin Wang

Published online: 23 December 2025

Original Article

Frailty assessed using the Liver Frailty Index^TM (LFI) is a risk factor for mortality in patients with advanced hepatocellular carcinoma treated with atezolizumab-bevacizumab

Philippe Sultanik, Claudia Campani, Sarah Mouri, Eleonore Spitzer, Mathilde Wagner, Lorraine Blaise, Marie Lequoy, Violaine Ozenne, Jean Charles Nault, Dominique Thabut, Nathalie Ganne-Carrié, Manon Allaire

Published online: 12 December 2025

Original Article

Influence of metabolic dysfunction-associated steatotic liver disease and metabolic risk factors on immunotherapy outcomes in hepatocellular carcinoma with chronic hepatitis B

Xin-Tong Wu, Jun-Zhe Yi, Yi-Min Zhang, Jiong-Liang Wang, Lei Li, Jiang-Zheng Zeng, Ke Ding, Yu-Wen Fan, Xin Liu, Zhi-Jian Zhu, Dao-Zu Yuan, Shang-Fu Ning, Jian-Zhong Zhang, Yong-Fei You, Jie Xu, Rong-Ping Guo, Min-Shan Chen, Ming Zhao, Ning Lyu

Published online: 11 December 2025

Original Article

Clinical outcomes of hepatectomy after partial response to immune checkpoint inhibitor-based combination therapy in patients with extrahepatic hepatocellular carcinoma metastasis

Ziyue Huang, Shanshan Wang, Cong Ning, Kai Liu, Mingjian Piao, Xiangqi Chen, Nan Zhang, Yang Tan, Shuofeng Li, Jiongyuan Li, Chengjie Li, Ziyu Xun, Junwei Zhang, Jin Bian, Xiao Liu, Chengpei Zhu, Lei Zhang, Xiaobo Yang, Shunda Du, Haitao Zhao

Published online: 10 December 2025

Original Article

Evolving treatment strategies and management protocols for spontaneously ruptured hepatocellular carcinomas: a 30-year comparative analysis

Mingyang Li, Audrey Rolane Cheung, Kim Ho Kam Yuen, Kin Pan Au, Wing Chiu Dai, Simon Hing Yin Tsang, Sheung Tat Fan, Chung Mau Lo, J. Michael Millis, Tan To Cheung

Published online: 04 December 2025

Original Article

Impact of laparoscopic Kasai portoenterostomy on long-term native liver survival in patients with biliary atresia: a multicentre propensity score-matched study

Yoichi Nakagawa, Yudai Tsuruno, Fanny Yeung, Masahiro Takeda, Akihiro Yasui, Toshio Harumatsu, Patrick Chung, Junya Ishii, Hiroo Uchida, Satoshi Ieiri, Kenneth Wong, Hiroyuki Koga

Published online: 24 November 2025

Review Article

Systematic review of portal and hepatic vein embolization for future liver remnant hypertrophy: feasibility, efficacy, and surgical outcomes of sequential and simultaneous methods

Kenichiro Araki, Ryosuke Fukushima, Kei Shibuya, Ken Shirabe

Published online: 11 November 2025

Review Article

Microvascular invasion in hepatocellular carcinoma: a detailed narrative review of definitions, predictions, and therapeutic strategies

Zhen-Bang Lou, Ju-Xian Sun, Jie Shi, Chang Liu, Ru-Jing Yuan, Shuqun Cheng

Published online: 31 October 2025

Original Article

Application of liver transplant techniques in complex liver surgery: modified techniques and preliminary results of complex liver resection using in-situ hypothermic portal perfusion without venovenous bypass

Bangyou Zuo, Xinyu You, Jipeng Jiang, Donghui Cheng, Peng Li, Pan He, Chong Yang, Yu Zhang

Published online: 17 October 2025

Review Article

Ruptured hepatocellular carcinoma: a narrative review

Feng Xia, Xulin Liu, Jing Yan, Xiaoping Chen, Qi Cheng, Bixiang Zhang, Peng Zhu

Published online: 24 September 2025

Original Article

Local treatments are safe and effective for recurrent hilar cholangiocarcinoma: a retrospective cohort study

Yanxin Chang, Jicheng Duan, Milan Zhong, Meiling Chen, Xintong Shi, Mengwen Hu, Xiaohui Fu, Lei Yin, Yongjie Zhang, Wenlong Yu

Published online: 19 September 2025

Original Article

Surgical stratification of left-sided hepatocellular carcinoma: development, validation, and survival impact

Qingyun Xie, Xin Zhao, Tianyang Mao, Haifeng Wan, Yinghao Lyu, Manyu Yang, Hongyuan Wang, Peng Zheng, Kangyi Jiang, Jiayin Yang, Fengwei Gao, Hong Wu

Published online: 01 September 2025

Original Article

Does preoperative routine statin use reduce post-hepatectomy liver failure?—an international multicentre retrospective cohort study on 2,342 patients

Florian Primavesi, Nicholas Syn, Thomas Niederwieser, Kamil Pufal, Benedikt Rumpf, Ahmed Ghoneima, Eva Braunwarth, Benno Cardini, Mattias Mandorfer, Felix Julius Krendl, Florian Ponholzer, Sophie Schindler, Rupert Oberhuber, Manuel Maglione, Dietmar Öfner, Stefan Schneeberger, Keith Roberts, Magdy Attia, Patrick Starlinger, Bobby V. M. Dasari, Stefan Stättner

Published online: 26 August 2025

Original Article

Impact of PD-L1 promoter methylation on lymph node metastasis and neoadjuvant treatment response in pancreatic ductal adenocarcinoma

Xinyuan Chen, Shanyue Sun, Jiapeng Zhao, Shuangni Yu, Jie Chen, Xianlong Chen

Published online: 22 August 2025

Original Article

Application of optical coherence tomography in intraoperative evaluation of perihilar cholangiocarcinoma: a prospective diagnostic study

Jianping Song, Chuanhao Zhang, Yangxi Li, Ming Xiao, Zhiqing Bai, Xiaojuan Wang, Hongen Liao, Shuo Jin, Canhong Xiang, Jiahong Dong

Published online: 20 August 2025

Original Article

Ex vivo liver resection and auto-transplantation for cholangiocarcinoma: a retrospective cohort study

Xin Han, Yang Huang, Chenlu Hu, Haoliang He, Yixing Zhang, Hongfan Ding, Juehua Xu, Ming Chao, Risheng Yu, Zhongquan Sun, Sheng Yan, Yuan Ding, Weilin Wang

Published online: 14 August 2025

Original Article

Hyperinsulinemic normoglycemia reduces postoperative hepatic dysfunction in patients undergoing major liver resection: a randomized controlled trial

Ahmed Al Gharrash, Ahmad Adib Awad, Peter Metrakos, Prosanto Chaudhury, Jennifer Kalil, Bon-Wook Koo, Yara Moussa, Hiroaki Sato, Thomas Schricker

Published online: 12 August 2025

Review Article

Advances in assessment methods for pancreatic fibrosis: a narrative review

Yixiao Liu, Hemiao Xu, Kehan Jin, Yaping Luo, Yunlu Feng, Aiming Yang

Published online: 07 August 2025

Original Article

Outcomes of small-size graft in highly urgent living donor liver transplantation: Korean national data

Jongman Kim, Sang Jin Kim, Boram Park, Kyunga Kim, Young Rok Choi, Geun Hong, Jun Yong Park, Young Seok Han, Nam-Joon Yi, Seung Heui Hong, Soon-Young Kim, Jung-Bun Park, Youngwon Hwang, Dong-Hwan Jung

Published online: 18 July 2025

Original Article

Predictors for unsatisfactory thrombectomy and performance of non-anatomical portal vein reconstruction in liver transplant with preoperative occlusive portal vein thrombosis: a registry-based cohort study

Yong-Fa Huang, Ru-Zhou Cai, Lin Wei, Wei Qu, Zhi-Gui Zeng, Hai-Ming Zhang, Yu-Le Tan, Jun Wang, Fu-Xiao Xie, Li-Ying Sun, Zhi-Jun Zhu

Published online: 17 July 2025

Original Article

Short- and long-term outcomes and cost-effectiveness of robotic-assisted versus laparoscopic liver resection for Barcelona Clinic Liver Cancer (BCLC) 0/A hepatocellular carcinoma: a multicenter propensity score-matched analysis

Feng Xia, Xulin Liu, Jing Yan, Zhancheng Qiu, Qiao Zhang, Zhenheng Wu, Zhiyuan Huang, Renjie Wei, Li Lin, Liping Liu, Shuangqin Han, Huaxuan Yin, Guobing Xia, Yunyan Wan, Jian Li, Xiafei Xia, Huapeng Sun, Shuai Wang, Jun Zheng, Hengyi Gao, Li Ren, Ali Mo, Junquan Fu, Lin Ye, Wei Zhou, Xiaoping Chen, Peng Zhu, Bixiang Zhang, Zhiwei Zhang, Qi Cheng

Published online: 07 July 2025

Original Article

Combined treatment of budesonide and ursodeoxycholic acid for non-cirrhotic primary biliary cholangitis: a systematic review and meta-analysis

Kun He, Kai Song, Lisha Jing, Daiyu Yang, Chengzhen Lyu, Ziqi Guo, Hemiao Xu, Hui Xu, Huijun Shu, Yangzhong Zhou, Can Huang, Dong Wu

Published online: 14 May 2025

Original Article

A new TNM T3 subclassification with corresponding prognostic stage grouping for gallbladder cancer: a multicenter retrospective study

Facai Yang, Tianhang Su, Zhengqing Lei, Zhimin Geng, Jingdong Li, Kai Zhang, Jun Ding, Xuewu Tang, Weihu Ma, Cheng Chi, Zhaohui Tang, Yinghe Qiu, Zhangjun Cheng, Bin Yi

Published online: 13 May 2025

Original Article

Body mass index and ampulla of Vater cancer incidence and survival: a cohort study of 1.7 million Norwegians

Dagfinn Aune, Marie Nordsletten, Tor Åge Myklebust, Trude Eid Robsahm, Bjørn Steen Skålhegg, Tom Mala, Sheraz Yaqub, Usman Saeed

Published online: 07 May 2025

Original Article

Dynamic changes of pathophysiological characteristics during liver regeneration induced by associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)

Jiayan Yan, Zhifeng Jiang, Shiyu Zhang, Runze Miao, Na Yao, Feiyu Chen, Dezhen Guo, Rongkui Luo, Senquan Zhang, Xinyu Wang, Junfeng Huang, Zheng Wang, Zhaoyou Tang, Jia Fan, Ao Huang, Yuan Ji, Hans J. Schlitt, Xinrong Yang, Jian Zhou

Published online: 17 April 2025

Journal Highlight more

The Hepatobiliary Surgery and Nutrition is an international, open access, peer-reviewed journal indexed in PubMed and Science Citation Index Expanded (SCIE), covering the field of surgical techniques, clinical and basic researches, transplantation and other therapies, related imaging, biology, pathology, immunology, targeted drug and molecular developments and technical advances, etc.

Indexing

HepatoBiliary Surgery and Nutrition is indexed and covered by

Visual Abstract

Visual abstracts, also called 'graphical abstracts' or 'infographics,' are images that summarize the essential information of manuscripts, providing an easily and expediently understood overview of study findings at a glance. More >>