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Original Article

Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation
Chen Wang, Zhao-Yan Liu, Wen-Ge Huang, Zhi-Jun Yang, Qiu-Ye Lan, Ai-Ping Fang, Meng-Jun Hou, Xiao-Lin Luo, Yao-Jun Zhang, Si Chen, Hui-Lian Zhu
Our study demonstrated that choline inhibited HCC malignant progression by suppressing AMPK/mTOR-mediated autophagy via SLC5A7 upregulation. In addition, choline worked synergistically with sorafenib to enhance its antitumor effect, which may provide a new strategy for HCC treatment in the future.
Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis
Shi-Chuan Tang, Yong-Kang Diao, Kong-Ying Lin, Chao Li, Xiao Xu, Lei Liang, Jie Kong, Qing-Jing Chen, Xian-Ming Wang, Fu-Bao Liu, Wei-Min Gu, Ya-Hao Zhou, Ying-Jian Liang, Hong-Zhi Liu, Ming-Da Wang, Lan-Qing Yao, Timothy M. Pawlik, Feng Shen, Wan Yee Lau, Tian Yang, Yong-Yi Zeng
Using two propensity score methods and competing-risk regression analysis, the effect of Pringle maneuver on long-term prognosis of hepatocellular carcinoma after hepatectomy was clarified. Not applying the Pringle maneuver during hepatectomy was independently associated with lower cumulative recurrence rate and cancer-specific mortality.
A single center analysis of long-term outcomes and survival related risk factors in liver retransplantation
Zhihao Li, Yi Ping Sng, Chao-Long Chen, Chih-Che Lin, Shih-Ho Wang, Chee-Chien Yong
Liver retransplantation with living donor graft in hands of experienced team with refined technique showed optimal long-term outcome and it is irrelevant of the timing of retransplantation. Long warm ischemia time and intraoperative massive blood transfusion negatively impact patient’s survival.
Laparoscopic versus open surgery in treating patients with gallbladder cancer: a systematic review and meta-analysis
Duo Li, Li Xu, Xiangling Deng, Yongliang Sun, Zihuan Zhang, Tianxiao Wang, Ruili Wei, Yingjixing Luo, Wenquan Niu, Zhiying Yang
This systematic review and meta-analysis revealed that LS had better survival rates, less intraoperative bleeding, shorter hospitalization times, and lower rates of complications than OS from statistical aspects. However, the superiority and safety of LS still remain uncertain due to unaccounted confounding impact.
Impact of preoperative chemotherapy on surgical results in 139 patients with locally advanced pancreatic cancer
Marvin Petrikowski, Tim Fahlbusch, Anke Reinacher-Schick, Giedre Kucinskaite, Andrea Tannapfel, Waldemar Uhl, Orlin Belyaev
Preoperative chemotherapy enables resectability of initially unresectable patients with LAPC without increasing perioperative mortality and morbidity. The combination of preoperative chemotherapy and consecutive surgery improves recurrence-free and overall survival in a real-world data set.

Review Article

Pathologic assessment of hepatocellular carcinoma in the era of immunotherapy: a narrative review
Han Wang, You-Wen Qian, Hui Dong, Wen-Ming Cong
This review summarized the research progress of pathologic assessment related to immunotherapy of hepatocellular carcinoma. A precise histological evaluation of specimens underwent immunotherapy and predictive biomarkers of immunotherapy should be highly focused on for the pathologists.

Surgical Technique

3D laparoscopic anatomical hepatectomy guided by 2D real-time indocyanine green fluorescence imaging for hepatocellular carcinoma
Feng Tian, Li Cao, Jian Chen, Shuguo Zheng, Jianwei Li
We propose a new procedure, 3D laparoscopic anatomical hepatectomy (LAH) with 2D real-time ICG (r-ICG) guidance for HCC treatment. In this procedure, the advantages of two techniques, 3D laparoscopy and 2D r-ICG guidance, were combined so that LAH might be performed with more precision.

Editorial Commentary

Inflammatory indicators such as systemic immune inflammation index (SIII), systemic inflammatory response index (SIRI), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic factors of curative hepatic resections for hepatocellular carcinoma
Paschalis Gavriilidis, Timothy M. Pawlik
Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society Consensus Conference: towards better clinical care in transplant hepatology
Yu Jun Wong, Noreen Singh, Norberto Sanchez-Fernandez, Aldo J. Montano-Loza
Insights on liver-directed surgical innovations, targeted therapies, and immunotherapy for biliary tract cancer: navigating the new European Society for Medical Oncology (ESMO) Clinical Practice Guidelines
Ajay V. Maker
Early bifurcation of hepatic artery in right-sided living-donor hepatectomy at Asan Medical Center: rarely a critical issue
Deok-Bog Moon, Gil-Chun Park, Sang Hoon Kim, Sung-Min Kim
Exocrine pancreatic insufficiency: more compromise than precision
Matteo Tacelli, Paolo Giorgio Arcidiacono, Gabriele Capurso
Preoperative assessment of liver function and perioperative management of posthepatectomy liver failure
Masahiro Shiihara, Mitsugi Shimoda, Shuji Suzuki
A novel non-invasive model to predict high-risk varices in cirrhotic patients
Kelvin K. C. Ng
Non-invasive strategies to predict post-hepatectomy liver failure
Anna Cavazza, Michael A. Heneghan
Albumin use in cirrhosis: a nephrology viewpoint on key considerations and cautionary notes
Abhilash Koratala, Amir Kazory
Reassessing the impact of post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy on mortality in patients with cirrhosis
Qiuju Ran, Zhang Wen, Shuyue Tuo, Jinhai Wang, Xinxing Tantai

Images in Clinical Medicine

Cystic hepatic echinococcosis with intrabiliary rupture
Jianming Ma, Qifu Yan, Zha Xi Yun Dan, Yucheng Hou, Rui Tang

Review Article

Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings
Taylor Francis, Allyson Graf, Kyle Hodges, Lindsey Kennedy, Laura Hargrove, Mattie Price, Kate Kearney, Heather Francis
Liver transplantation for hepatocellular carcinoma
Jerome Byam, John Renz, J. Michael Millis
Hilar cholangiocarcinoma: diagnosis, treatment options, and management
Kevin C. Soares, Ihab Kamel, David P. Cosgrove, Joseph M. Herman, Timothy M. Pawlik

Original Articles

Correlation between 3D-MRCP and intra-operative findings in right liver donors
Aly Ragab, Reyold I. Lopez-Soler, Aytekin Oto, Giuliano Testa
Diagnosis and treatment of hepatic angiomyolipoma
Shunda Du, Ying Li, Yilei Mao, Xinting Sang, Xin Lu, Wenze Wang, Qing Zhang, Huadan Xue, Xiaobo Yang, Shaohua Li, Tianyi Chi, Shouxian Zhong, Jiefu Huang
Liver transplantation in mainland China: the overview of CLTR 2011 annual scientific report
Haibo Wang, Wenshi Jiang, Zhiye Zhou, Jianyan Long, Wen Li, Sheung Tat Fan
Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang

Original Article

Inhibition of the liver expression of arylalkylamine N-acetyltransferase increases the expression of angiogenic factors in cholangiocytes
Anastasia Renzi, Romina Mancinelli, Paolo Onori, Antonio Franchitto, Gianfranco Alpini, Shannon Glaser, Eugenio Gaudio

Review Article

Melatonin regulation of biliary functions
Shannon Glaser, Yuyan Han, Heather Francis, Gianfranco Alpini


Risk stratification for Hepatitis B treatment in the molecular age
Sanjay R. Mehta, Alexander Kuo

Original Articles

Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats
Qinyuan Ye, Fuzhi Lian, Pollyanna R.G. Chavez, Jayong Chung, Wenhua Ling, Hua Qin, Helmut K. Seitz, Xiang-Dong Wang
Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions
Antonio J. Melendez-Martinez, Andre F. Nascimento, Yan Wang, Chun Liu, Yilei Mao, Xiang-Dong Wang

Review Articles on Liver Immunology: Part 2

Contribution of bone marrow-derived fibrocytes to liver fibrosis
Jun Xu, Min Cong, Tae Jun Park, David Scholten, David A. Brenner, Tatiana Kisseleva

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 1

Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice
Bruna Paola Murino Rafacho, Camilla Peach Stice, Chun Liu, Andrew S. Greenberg, Lynne M. Ausman, Xiang-Dong Wang

Original Article on Fatty Liver Disease and Nutrient Intervention: Part 2

DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis
Jason J. Yuen, Seung-Ah Lee, Hongfeng Jiang, Pierre-Jacques Brun, William S. Blaner

Review Article on Retinoid Biology: Part I

STRA6: role in cellular retinol uptake and efflux
Mary Kelly, Johannes von Lintig

Original Article on Retinoid Biology: Part I

Alcohol exposure in utero perturbs retinoid homeostasis in adult rats
Youn-Kyung Kim, Michael V. Zuccaro, Changqing Zhang, Dipak Sarkar, Loredana Quadro

Below are the latest Hepatobiliary Surgery and Nutrition articles published online ahead of print publication.

Original Article
The differential benefit of laparoscopic over open minor liver resection for lesions situated in the anterolateral or posterosuperior segments
Jasper P. Sijberden, Guido Fiorentini, Jacopo Lanari, Davit Aghayan, Daniel Osei-Bordom, Nadia Russolillo, Arjun Takhar, Andrea Benedetti Cacciaguerra, Santi Lopez-Ben, Mathieu D’Hondt, Felice Giuliante, David Fuks, Fernando Rotellar, Andrea Ruzzenente, Adnan Alseidi, Mikhail Efanov, Burak Görgec, Giuseppe Zimmitti, Enrico Gringeri, Federica Cipriani, Åsmund Avdem Fretland, Ravi Marudanayagam, Marco Vivarelli, John N. Primrose, Alessandro Ferrero, Robert P. Sutcliffe, Bjørn Edwin, Umberto Cillo, Marc G. Besselink, Mohammad Abu Hilal, Luca A. Aldrighetti
Published online: 04 July 2024
Original Article
Long- and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection: a multicenter propensity score-matched comparative study
Zhi-Peng Liu, Xing-Xing Su, Long-Fei Chen, Xue-Lei Li, Yi-Shi Yang, Zhi-Long You, Xiao-Lin Zhao, Fan Huang, Chao Yu, Zhao-Ping Wu, Wei Chen, Jin-Xue Zhou, Wei Guo, Da-Long Yin, Ping Yue, Rui Ding, Yi Zhu, Wei Chen, Yan Jiang, Jie Bai, Jing-Jing Wang, Yan-Qi Zhang, Dong Zhang, Hai-Su Dai, Wan Yee Lau, Zhi-Yu Chen; The Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery (EGCDS)
Published online: 16 May 2024
Review Article
The Dallas Donation after Circulatory Death Transplantation Summit: expanding donation after circulatory death procedures through process improvement, broader utilization, and innovation
Michele Finotti, Anji Wall, Anthony D’Alessandro, Gary Schwartz, Chris Sonnenday, David Goldberg, Ashish Shah, Peter Friend, Jeff P. Orlowski, Greg McKenna, Steve Newton, Brad Adams, William C. Chapman, Amit Mathur, Marwan Abouljoud, Tim Pruett, Amelia Hessheimer, James F. Trotter, Sumeet K. Asrani, Giuliano Testa
Published online: 25 April 2024