Vol 13, No 3 (June 01, 2024): Hepatobiliary Surgery and Nutrition

Original Article

Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation
Chen Wang, Zhao-Yan Liu, Wen-Ge Huang, Zhi-Jun Yang, Qiu-Ye Lan, Ai-Ping Fang, Meng-Jun Hou, Xiao-Lin Luo, Yao-Jun Zhang, Si Chen, Hui-Lian Zhu
Our study demonstrated that choline inhibited HCC malignant progression by suppressing AMPK/mTOR-mediated autophagy via SLC5A7 upregulation. In addition, choline worked synergistically with sorafenib to enhance its antitumor effect, which may provide a new strategy for HCC treatment in the future.
Association of Pringle maneuver with postoperative recurrence and survival following hepatectomy for hepatocellular carcinoma: a multicenter propensity score and competing-risks regression analysis
Shi-Chuan Tang, Yong-Kang Diao, Kong-Ying Lin, Chao Li, Xiao Xu, Lei Liang, Jie Kong, Qing-Jing Chen, Xian-Ming Wang, Fu-Bao Liu, Wei-Min Gu, Ya-Hao Zhou, Ying-Jian Liang, Hong-Zhi Liu, Ming-Da Wang, Lan-Qing Yao, Timothy M. Pawlik, Feng Shen, Wan Yee Lau, Tian Yang, Yong-Yi Zeng
Using two propensity score methods and competing-risk regression analysis, the effect of Pringle maneuver on long-term prognosis of hepatocellular carcinoma after hepatectomy was clarified. Not applying the Pringle maneuver during hepatectomy was independently associated with lower cumulative recurrence rate and cancer-specific mortality.
A single center analysis of long-term outcomes and survival related risk factors in liver retransplantation
Zhihao Li, Yi Ping Sng, Chao-Long Chen, Chih-Che Lin, Shih-Ho Wang, Chee-Chien Yong
Liver retransplantation with living donor graft in hands of experienced team with refined technique showed optimal long-term outcome and it is irrelevant of the timing of retransplantation. Long warm ischemia time and intraoperative massive blood transfusion negatively impact patient’s survival.
Laparoscopic versus open surgery in treating patients with gallbladder cancer: a systematic review and meta-analysis
Duo Li, Li Xu, Xiangling Deng, Yongliang Sun, Zihuan Zhang, Tianxiao Wang, Ruili Wei, Yingjixing Luo, Wenquan Niu, Zhiying Yang
This systematic review and meta-analysis revealed that LS had better survival rates, less intraoperative bleeding, shorter hospitalization times, and lower rates of complications than OS from statistical aspects. However, the superiority and safety of LS still remain uncertain due to unaccounted confounding impact.
Impact of preoperative chemotherapy on surgical results in 139 patients with locally advanced pancreatic cancer
Marvin Petrikowski, Tim Fahlbusch, Anke Reinacher-Schick, Giedre Kucinskaite, Andrea Tannapfel, Waldemar Uhl, Orlin Belyaev
Preoperative chemotherapy enables resectability of initially unresectable patients with LAPC without increasing perioperative mortality and morbidity. The combination of preoperative chemotherapy and consecutive surgery improves recurrence-free and overall survival in a real-world data set.

Review Article

Pathologic assessment of hepatocellular carcinoma in the era of immunotherapy: a narrative review
Han Wang, You-Wen Qian, Hui Dong, Wen-Ming Cong
This review summarized the research progress of pathologic assessment related to immunotherapy of hepatocellular carcinoma. A precise histological evaluation of specimens underwent immunotherapy and predictive biomarkers of immunotherapy should be highly focused on for the pathologists.

Surgical Technique

3D laparoscopic anatomical hepatectomy guided by 2D real-time indocyanine green fluorescence imaging for hepatocellular carcinoma
Feng Tian, Li Cao, Jian Chen, Shuguo Zheng, Jianwei Li
We propose a new procedure, 3D laparoscopic anatomical hepatectomy (LAH) with 2D real-time ICG (r-ICG) guidance for HCC treatment. In this procedure, the advantages of two techniques, 3D laparoscopy and 2D r-ICG guidance, were combined so that LAH might be performed with more precision.

Editorial Commentary

Inflammatory indicators such as systemic immune inflammation index (SIII), systemic inflammatory response index (SIRI), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic factors of curative hepatic resections for hepatocellular carcinoma
Paschalis Gavriilidis, Timothy M. Pawlik
Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society Consensus Conference: towards better clinical care in transplant hepatology
Yu Jun Wong, Noreen Singh, Norberto Sanchez-Fernandez, Aldo J. Montano-Loza
Insights on liver-directed surgical innovations, targeted therapies, and immunotherapy for biliary tract cancer: navigating the new European Society for Medical Oncology (ESMO) Clinical Practice Guidelines
Ajay V. Maker
Early bifurcation of hepatic artery in right-sided living-donor hepatectomy at Asan Medical Center: rarely a critical issue
Deok-Bog Moon, Gil-Chun Park, Sang Hoon Kim, Sung-Min Kim
Exocrine pancreatic insufficiency: more compromise than precision
Matteo Tacelli, Paolo Giorgio Arcidiacono, Gabriele Capurso
Preoperative assessment of liver function and perioperative management of posthepatectomy liver failure
Masahiro Shiihara, Mitsugi Shimoda, Shuji Suzuki
A novel non-invasive model to predict high-risk varices in cirrhotic patients
Kelvin K. C. Ng
Non-invasive strategies to predict post-hepatectomy liver failure
Anna Cavazza, Michael A. Heneghan
Albumin use in cirrhosis: a nephrology viewpoint on key considerations and cautionary notes
Abhilash Koratala, Amir Kazory
Reassessing the impact of post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy on mortality in patients with cirrhosis
Qiuju Ran, Zhang Wen, Shuyue Tuo, Jinhai Wang, Xinxing Tantai

Images in Clinical Medicine

Cystic hepatic echinococcosis with intrabiliary rupture
Jianming Ma, Qifu Yan, Zha Xi Yun Dan, Yucheng Hou, Rui Tang