Vol 15, No 4 (August 01, 2026): HepatoBiliary Surgery and Nutrition

Original Article

Liver donor macrosteatosis is associated with adverse long-term outcomes exclusively in metabolic dysfunction-associated steatotic liver disease recipients: a U.S. transplant registry analysis over the last decade
Leandro Sierra, Butros Fakhoury, Kanisha Bahierathan, Maria Saavedra-Martinez, Maria Ortega Abad, Lily Liu, Vinay Jahagirdar, Pojsakorn Danpanichkul, Katherine M. Cooper, Luis Antonio Diaz, Juan Pablo Arab
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:97
.
Liver grafts with >30% macrovesicular steatosis were associated with significantly lower early and long-term graft survival in MASLD recipients but showed no such association in MetALD or ALD recipients. Our study suggests steatotic graft allocation in liver transplantation should be guided by recipient SLD subtype.
Optimal timing of reoperation for postoperatively diagnosed T2 gallbladder cancer: a retrospective multicenter cohort study
Yeshong Park, Jinju Kim, MeeYoung Kang, Boram Lee, Hae Won Lee, Jai Young Cho, Ho-Seong Han, Dae Wook Hwang, Chang Moo Kang, Chi-Young Jeong, Wan-Joon Kim, Yoo-Seok Yoon
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:98
.
The optimal timing of reoperation for postoperatively diagnosed T2 gallbladder cancer is 4 to 8 weeks after the initial cholecystectomy. Early reoperation is associated with worse perioperative outcomes, while delayed reoperation is associated with higher risk of recurrence.
Independent risk factors for clinically relevant postoperative pancreatic fistula after robotic pancreatoduodenectomy: the protective role of the modified Blumgart pancreatojejunostomy in a single surgeon retrospective cohort of 220 cases
Abdallah Iben-Khayat, Amaury Facque, Guillaume Beraud, Baudouin Thebault, Willy Serge Mfam, Jean-Emanuel Langdorph, Olivier Saint-Marc, Haythem Najah
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:99
.
In a single-surgeon series of 220 robotic pancreatoduodenectomies, standardization of the modified Blumgart pancreatojejunostomy significantly reduced clinically relevant pancreatic fistula rates. Risk-adjusted learning curve analysis showed earlier achievement of proficiency and mastery, supporting routine adoption of this anastomosis during robotic program implementation.
When is enough enough?—predicting adequacy of portal vein embolization for hypertrophy of the future liver remnant in the age of liver venous deprivation
Antony Haddad, Reed I. Ayabe, Andrew D. Newton, Harufumi Maki, Mateo Lendoire, Yun Shin Chun, Ching-Wei D. Tzeng, Bruno C. Odisio, Steven Y. Huang, Jean-Nicolas Vauthey, Timothy E. Newhook, Hop S. Tran Cao
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:100
.
Patients with pre-PVE sFLR <19% and those with gross liver abnormalities or planned for staged or extended right hepatectomy are unlikely to achieve adequate liver remnant hypertrophy with PVE and may benefit from other measures like LVD.
Systematic review and meta-analysis of robotic versus laparoscopic radical cholecystectomy for gallbladder cancer
Hiang Jin Tan, Michelle Shi Qing Khoo, Xuan Han Koh, Nita Thiruchelvam, Adrian Kah Heng Chiow
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:101
.
Robotic surgery is shown to be safe, effective and appears to have better short-term outcomes in comparison to laparoscopic radical cholecystectomy. However, further studies and data are required to validate robotic radical cholecystectomy as the safe and feasible approach.
Monitoring with plasma apolipoprotein A2-isoforms can predict developing new-onset steatotic liver disease caused by pancreatic exocrine insufficiency following pancreatectomy
Akira Matsushita, Takashi Ono, Daigo Yoshimori, Akira Hamaguchi, Takahiro Murokawa, Junji Ueda, Tetsuya Shimizu, Yoichi Kawano, Masato Yoshioka, Mampei Kawashima, Yoshiharu Nakamura, Kengo Nagashima, Yuta Hasegawa, Tomonari Kiriyama, Keiko Takeuchi, Ayumi Kashiro, Kazufumi Honda, Hiroshi Yoshida
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:102
.
New-onset steatotic liver disease (SLD) is increasingly reported after pancreatectomy. In this retrospective study, low plasma ApoA2-AT/AT levels (<9.58 µg/mL) significantly correlated with post-operative SLD and were an independent risk factor. ApoA2 isoforms represent a useful biomarker for assessing pancreatic exocrine function and predicting SLD.

Clinical Practice Guideline

Diagnostic and management guidelines for biliary atresia in 2025
Liang Ge, Jixin Yang, Tengfei Li, Tianqi Zhu, Mark Davenport, Claus Petersen, Taylor Jacobs, Robin Petroze, Jianshe Wang, Kenneth Kak Yuen Wong, Zhibo Zhang, Wei Gao, Sainan Shu, Ping Yin, Shujian Zhang, Yajun Chen, Zhibao Lv, Shuguang Jin, Zhe Wen, Bin Wang, Weibing Tang, Jinfa Tou, Qiang Yin, Bin Xu, Linsheng Zhao, Wanfu Li, Xueqiang Yan, Shengqiao Zhao, Yuanmei Liu, Xiang Liu, Hua Huang, Shungen Huang, Pu Yu, Hongxia Ren, Yingchao Li, Huizhong Niu, Alimujiang Abudureyimu, Xin Li, Shaowen Liu, Rongjuan Sun, Heying Yang, Mingman Zhang, Xiaoke Dai, Mureo Kasahara, George V. Mazariegos, Yanjun Shi, Masaki Nio, Thanh Liem Nguyen, Vincent Chi Hang Lui, Hiroo Uchida, Gail E. Besner, Ronald B. Hirschl, Jianghua Zhan, Jiexiong Feng
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:103
.
This consensus summarizes the latest literature on BA and brings together 23 opinions and recommendations from 50 experts from both East and West. International guidelines for BA can provide guidance on current practice for surgeons, patients, medical societies, hospital administrators, and relevant community groups.

French Editorial Commentary from the ACHBPT

Liver transplantation changes the rules for colorectal liver metastases
Diana Berzan, Stylianos Tzedakis, Heithem Jeddou
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:104
.
Total pancreatectomy friend or foe?
Emmanuel Devant, Mircea Chirica
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:105
.

Editorial Commentary

Postoperative hyperamylasemia—an early warning signal after distal pancreatectomy
Bernhard W. Renz, Jens Werner
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:106
.
Precision of computed tomography volumetry in living donor liver transplantation: current evidence, limitations, and future directions
Yu Saito, Yuji Morine, Shinichiro Yamada, Hiroki Teraoku, Katsuki Miyazaki, Tetsuya Ikemoto
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:107
.
Sexual dimorphism in liver cancer recurrence: the role of SRY and ischemia-reperfusion injury
Ranish K. Patel, Skye C. Mayo
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:108
.
Hepatitis B virus-specific T cell receptor therapy for advanced hepatocellular carcinoma: lessons from Wu et al.
Rashmi Kumar, Irina Dobrosotskaya, Timothy L. Frankel
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:109
.
The era of minimally invasive pancreatic surgery: is the robot ready to replace laparoscopy for extended left pancreatectomy?
Kai Siang Chan, Vishal G. Shelat
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:110
.
Are we ready for a molecular diagnostics-driven era in hepatobiliary surgery?
Zi-Jie Tang, Jia-Hao Xu, Li-Hui Gu, Xin Li, Tian Yang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:111
.
Dual TIGIT and PD-1 blockade in immunotherapy-refractory hepatocellular carcinoma: a signal beyond resistance?
Maria Stella Franzè, Giuliana Amaddeo
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:112
.
DGAT2 inhibition in MASH: histologic promise and lipid paradox
Sarpong Boateng, Chloe Bennett, Reda M. Al Badawy, Thiruvengadam Muniraj
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:113
.
Surgical data extractivism: the false promise of institutional custodianship
Yu-Han Cui, Jia-Qi Du, Guo-Wei Wang, Zi-Jie Tang, Tian Yang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:114
.
Spatial architecture and dynamic surveillance: 3D bioprinting and microfluidics converge to overcome digestive malignancies
Congcong Zhang, Junjing Yang, Xia Xiao, Weiming Yu, Xianlei Cai
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:115
.
Protein S-sulfhydration: an emerging regulatory layer with therapeutic potential in metabolic dysfunction-associated steatotic liver disease
Mingchang Pang, Huayu Yang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:116
.
From local control to immune synergy: the evolving role of stereotactic body radiotherapy in the immunotherapy era of hepatocellular carcinoma
Zihan Yan, Xiaorong Hou, Fuquan Zhang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:117
.
3D bioprinting in liver transplantation: from organ replacement to transplantable functional support
Kai Zhang, Shunda Du
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:118
.

Editorial

Evolution of minimally invasive surgery in gallbladder carcinoma: maintaining oncological radicality and the enduring value of open resection
Tomoyuki Abe, Shintaro Kuroda, Tsuyoshi Kobayashi, Hideki Ohdan
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:119
.

Letter to the Editor

Eggplant-like pancreas: transformation in a year
Jia Li, Songling Liu, Shihao Jiang, Yuansong He, Chao Chen, Wei Cheng, Lei Zhou
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:120
.
Significant portal hypertension: porto-sinusoidal vascular disease associated with atypical Adams-Oliver syndrome
Yi Song, Huabao Liu, Wenyan Hu, Ying Wan, Yi Huang, Chunyan Rao
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:121
.
Lack of blood may drive liver neoplasm: a case of an intrahepatic portosystemic venous shunt and liver focal nodular hyperplasia with elevation of serum PIVKA-II level
Yunhan Mao, Han Zheng, Xueshuai Wan, Yiyao Xu, Shunda Du
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:122
.
Pediatric ex-vivo liver resection and auto-transplantation for complex hepatic alveolar echinococcosis
Yucheng Hou, Di Wu, Dong Feng, Lihan Yu, Hongqiang Zhao, Guangdong Wu, Xueqing Li, Rui Tang, Qian Lu
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:123
.
From associations to action: deepening the clinical and mechanistic implications of obesity indices in T2DM risk stratification
Yuan Yang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:124
.
Obesity indices and type 2 diabetes risk: implications for dynamic assessment and metabolic mechanisms
Bo Wu, Yun Chen, Haitao Xu, Qi Zhao, Yue Chen, Xiaolian Dong, Chaowei Fu
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:125
.

Images in Clinical Medicine

Massive hepatic hemangioma complicated by Kasabach-Merritt syndrome
Xixi Gao, Jia Huang, Zhiying Yang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:127
.
Diaphragmatic hernia following right hemihepatectomy
Yuxiao Sun, Lei Zhang
HepatoBiliary Surgery and Nutrition  
2026;
15
(4)
:128
.