Vol 14, No 2 (April 01, 2025): Hepatobiliary Surgery and Nutrition

Original Article

Post-chemotherapy liver atrophy does not impact the outcome after hepatectomy performed under a parenchymal-sparing approach
Matteo Donadon, Virginia Laurenti, Simone Famularo, Benedetta Sargenti, Bruno Branciforte, Pio Corleone, Lucio Urbani, Guido Torzilli
Preoperative chemotherapy for patients with colorectal liver metastases (CLM) could induce hepatic atrophy. A higher degree of atrophy does not impact on postoperative morbidity, hepatic insufficiency and death in patients with CLM when undergoing post-chemotherapy resection with a parenchymal sparing procedure.
Laparoscopic hepatectomy and near-infrared fluorescence based on the concept of “biliary territory” in the treatment of hepatolithiasis: a propensity score-matched study with videos
Fengwei Gao, Qingyun Xie, Xin Zhao, Manyu Yang, Kangyi Jiang, Tianyang Mao, Jiayin Yang, Hong Wu
The study introduced the innovative concept of 'biliary territory' for near-infrared fluorescence (NIF) guidance during laparoscopic hepatectomy. This approach demonstrated potential advantages in reducing perioperative complications and stone recurrence compared with traditional white light laparoscopy.
Short- and long-term outcomes of laparoscopic versus open resection of perihilar cholangiocarcinoma: a propensity score-based analysis
Zhi-Peng Liu, Yue Wang, Yu Pan, Xiao-Lin Zhao, Long-Fei Chen, Xue-Song Li, Xiao-Jun Wang, Jian-Wei Li, Xian-Yu Yin, Jie Bai, Yan-Qi Zhang, Hai-Su Dai, Zhi-Yu Chen, Shu-Guo Zheng
Some short-term and intraoperative outcomes of GBC patients after LR were better, but the long-term outcomes did not significantly differ between patients who underwent LR and those who underwent OR. The use of AC after curative-intent resection of GBC helped achieve better long-term survival outcomes.
Prevalence and longitudinal effects on mortality associated with spectrum of alcohol intake in steatotic liver disease: a United States population study
Christen Ong, Nicole Tang, Shyna Gunalan, Margaret Teng, Benjamin Koh, Douglas Chee, Jia Hong Koh, Daniel Tung, Nicholas Syn, Dan Nakano, Anand Kulkarni, Michelle Law, Takao Miwa, Hirokazu Takahashi, Mark Muthiah, Karn Wijarnpreecha, George Ioannou, Cheng Han Ng, Daniel Q. Huang, Mazen Noureddin
The recently introduced terminologies MASLD, MetALD and ALD refer to different types of SLD associated with varying alcohol intake. They represent distinct conditions in terms of prevalence in the SLD population and mortality risks.
Endothelial glycocalyx damage marker syndecan-1 during hypothermic oxygenated machine perfusion of donor grafts facilitates prediction of early allograft dysfunction after liver transplantation
Laurin Rauter, Dagmar Kollmann, Judith Schiefer, Marija Spasic, Pierre Raeven, Jule Dingfelder, David Pereyra, David M. Baron, Effimia Pompouridou, Thomas Soliman, Gabriela Berlakovich, Georg Györi
Endothelial glycocalyx is highly sensitive to IRI. Its main component Syndecan-1 (Sdc-1) was evaluated as biomarker at multiple time points during hypothermic oxygenated machine perfusion (HOPE) for liver transplantation. Sdc-1 at 60 minutes during HOPE allowed identification grafts with severe risk of early allograft dysfunction.

Expert Consensus

Chinese expert consensus on the diagnosis and treatment of hepatocellular carcinoma with microvascular invasion (2024 edition)
Juxian Sun, Yong Xia, Feng Shen, Shuqun Cheng; on behalf of Chinese Association of Liver Cancer of Chinese Medical Doctor Association
Our consensus provides normative recommendations for the diagnosis, classification, prediction, and treatment of microvascular invasion(MVI) for the first time, which can better guide the treatment of MVI and improve the overall survival rate of hepatocellular carcinoma patients with MVI.

Editorial Commentary

Intraoperative blood loss in perihilar cholangiocarcinoma: should we aim below a certain cut-off?
Pim B. Olthof, Bas Groot Koerkamp
New practice guidelines on risk stratification and management of portal hypertension: towards a personalized multidisciplinary approach
Angelo Bruni, Luigi Colecchia, Elton Dajti, Giovanni Barbara, Francesco Azzaroli
Benchmark center volume and regional disparity in living donor liver transplantation
Ivan Vella, Fabrizio di Francesco, Sergio Li Petri, Duilo Pagano, Caterina Accardo, Giuseppe Mamone, Sergio Calamia, Salvatore Gruttadauria
Resmetirom as an important cornerstone of multidisciplinary management of metabolic dysfunction-associated steatohepatitis
Kahei Au, Wah Yang
Graft-to-recipient weight ratio: a timeless standard still shaping outcomes
Toshihiro Nakayama, Kazunari Sasaki
Associations of the gut microbiome and metabolites on biliary tract cancer: insight from a bidirectional two-sample Mendelian randomization study
Wen-Bo Zou, Jia-Ni Liu, Yuan-Shu Lian, Gao Huang
Efficacy and challenges of combining transarterial chemoembolization with pembrolizumab in advanced hepatocellular carcinoma: insights from the PETAL study
Qingyan Kong, Xiankun Wang, Zhuyu Chen, Wei Peng
Recurrence beyond Milan criteria following liver resection for early-stage hepatocellular carcinoma: incidence, prediction and implications for treatment selection
Diamantis I. Tsilimigras, Ioannis Ntanasis-Stathopoulos, Dimitrios Moris
Recurrence after neoadjuvant therapy for pancreatic cancer: same challenges, new opportunities
Taylor Neilson, Jordan M. Cloyd
Advancing the management of hepatocellular carcinoma: surrogate markers and predictive biomarkers for survival on immunotherapy
Naoshi Nishida
Shifting paradigm of quality of life after pancreatoduodenectomy for pancreas cancer
Kyuseok Im, Victoria V. O’Connor
High-volume living donor liver transplantation (LDLT): what the data tells us
Berkay Demirors, Michele Molinari
Innovations in liver organoids: the role of 3D bioprinting in creating functional organoids
Kai Zhang, Huayu Yang
Sarcopenia’s increasingly vital role in liver cancer
Xuelei Xu, Xinwei Pan, Hongshuang Chen, Yan Zhang, Weinan Liu