Vol 10, No 1 (February 03, 2021): Hepatobiliary Surgery and Nutrition

Original Article

How should liver hypertrophy be stimulated? A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and portal vein embolization (PVE) with rescue possibility
Ernesto Sparrelid, Kristina Hasselgren, Bård Ingvald Røsok, Peter Nørgaard Larsen, Nicolai Aagaard Schultz, Ulrik Carling, Eva Fallentin, Stefan Gilg, Per Sandström, Gert Lindell, Bergthor Björnsson
The different roles of ALPPS and PVE are still debated. This study shows that although upfront ALPPS offers higher resection rate than PVE the sequential use of PVE followed by ALPPS leads to improved hypertrophy compared to ALPPS upfront.
Severity of early allograft dysfunction following donation after circulatory death liver transplantation: a multicentre study
Kun Wang, Di Lu, Yuhui Liu, Wangyao Li, Li Zhuang, Zhenyu Ma, Qinfen Xie, Binhua Pan, Yichao Wu, Junli Chen, Lidan Lin, Xiaowen Feng, Qiang Wei, Xuyong Wei, Haiyang Xie, Zhengxin Wang, Shusen Zheng, Xiao Xu
Early allograft dysfunction (EAD) could be divided into type A and B. EAD type B was associated with decreased graft and recipient survival rates. The novel predictive model could effectively predict the incidence of EAD and EAD type B.
Machine learning predicts unpredicted deaths with high accuracy following hepatopancreatic surgery
Kota Sahara, Anghela Z. Paredes, Diamantis I. Tsilimigras, Kazunari Sasaki, Amika Moro, J. Madison Hyer, Rittal Mehta, Syeda A. Farooq, Lu Wu, Itaru Endo, Timothy M. Pawlik
Age-specific microbiota in altering host inflammatory and metabolic signaling as well as metabolome based on the sex
Lili Sheng, Prasant Kumar Jena, Ying Hu, Yu-Jui Yvonne Wan
This study revealed young female mice and aged male mice were the most insulin sensitive and resistant group, respectively. Aging reduced sex difference in insulin sensitivity. The age effect on inflammation and metabolism is transplantable, and the phenotypic outcomes change based on the recipient sex.

Review Article

Renewed considerations on the utility (or the futility) of hepatic resections for breast cancer liver metastases
Gian Luca Grazi
There are controversial data on the possibility to perform liver resections in patients with hepatic metastases from breast cancer. While oncologists consider these metastases to be a systemic disease, data from surgery seem to support a more aggressive attitude in these cases.
Hepatocellular carcinoma in non-alcoholic fatty liver disease—a review of an emerging challenge facing clinicians
Daniel Geh, Derek M. Manas, Helen L. Reeves
This narrative review discusses how non-alcoholic fatty liver disease (NAFLD) is fast becoming a leading cause of hepatocellular carcinoma (HCC) and the unique challenges this presents.
Biliary complications after liver transplantation: current perspectives and future strategies
Bianca Magro, Matteo Tacelli, Alessandra Mazzola, Filomena Conti, Ciro Celsa
BCs after LT range from 5% to 20%. Regarding etiology and risk factors there is a waste heterogeneity, but immunological features represent a future perspective. The best treatment for AS is endoscopic by the placement of multi stenting.

Editorial

An overview of the Chinese healthcare system
Baokang Yi
Hepatitis C—committing the world to an eradication of the infection
Johannes Wiegand, Thomas Berg
The gut-liver axis as a target of liver disease management
Claudia Mandato, Anna Pia Delli Bovi, Pietro Vajro
Addressing the variation in hepatic surgery for colorectal liver metastasis
Rachel V. Guest, Kjetil Søreide
Laparoscopic surgery for colorectal liver metastases: moving forward while keeping feet on the ground
Mariano Cesare Giglio, Roberto Ivan Troisi
Stool banking for fecal microbiota transplantation: ready for prime time?
Srishti Saha, Sahil Khanna
Predicting post-operative pancreatic fistula: one size may not fit all
Mariam F. Eskander, Jordan M. Cloyd
Current status of treatment for colorectal liver metastases in the United Kingdom
Kentaro Okamoto, Hiroyuki Uetake
Tenofovir vs. entecavir in reducing hepatocellular carcinoma risk in patients with chronic HBV infection?—Still an unsolved question
Hyun-Seok Kim, Hashem B. El-Serag
Non-alcoholic steatohepatitis or metabolic-associated fatty liver: time to change
Gamal Shiha, Nasser Mousa
Prognosis control surgery
Rong Liu, Qu Liu, Xiu-Ping Zhang

Disclosure:

1. The series “Images in Clinical Medicine” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.