Vol 11, No 2 (April 08, 2022): Hepatobiliary Surgery and Nutrition

The Story Behind the Cover Picture

Couinaud’s corrosion casts of the liver
Thomas M. van Gulik
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:174-175
.

Original Article

Development of a machine learning model to predict early recurrence for hepatocellular carcinoma after curative resection
Jianxing Zeng, Jinhua Zeng, Kongying Lin, Haitao Lin, Qionglan Wu, Pengfei Guo, Weiping Zhou, Jingfeng Liu
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:176-187
.
This study demonstrated that the machine learning model is a powerful tool to predict early recurrence and provides improvement over other models. This novel model may provide clinicians with useful guidance for postoperative follow-up and treatments.
Xanthophyll β-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status in β-carotene 9',10'-oxygenase knockout mice
Chun Liu, Bruna Paola M. Rafacho, Xiang-Dong Wang
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:188-198
.
High intake of provitamin A carotenoid beta-cryptoxanthin is related to a lower risk of nonalcoholic fatty liver disease (NAFLD). The study demonstrated that beta-cryptoxanthin has its own biological functions independent of carotenoid cleavage enzyme and functions as a promising preventative agent against NAFLD development.
Myeloid peroxisome proliferator-activated receptor α deficiency accelerates liver regeneration via IL-6/STAT3 pathway after 2/3 partial hepatectomy in mice
Guomin Xie, Yanting Song, Na Li, Zhenzhen Zhang, Xia Wang, Ye Liu, Shiyu Jiao, Ming Wei, Baoqi Yu, Yan Wang, Hua Wang, Aijuan Qu
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:199-211
.
Efficient liver regeneration is critical for the treatments of chronic liver diseases, such as donor liver transplantation and tumor resections. This study demonstrates that myeloid PPARα restricts PHx-induced liver regeneration via inhibiting IL-6/STAT3 pathway, thus providing a potential target for improving liver regeneration capacity.
A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease: a derivation and independent validation study
Zhong-Wei Chen, Huan-Ming Xiao, Xinjian Ye, Kun Liu, Rafael S. Rios, Kenneth I. Zheng, Yi Jin, Giovanni Targher, Christopher D. Byrne, Junping Shi, Zhihan Yan, Xiao-Ling Chi, Ming-Hua Zheng
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:212-226
.
This is the largest single study to assess the prediction of histologic hepatic inflammation by radiomics in NAFLD to date. A radiomics signature based on T2 weighted magnetic resonance imaging non-invasively and accurately identifies severe hepatic inflammation in patients with biopsy-proven NAFLD.

Review Article

Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)
Hui-Chuan Sun, Jian Zhou, Zheng Wang, Xiufeng Liu, Qing Xie, Weidong Jia, Ming Zhao, Xinyu Bi, Gong Li, Xueli Bai, Yuan Ji, Li Xu, Xiao-Dong Zhu, Dousheng Bai, Yajin Chen, Yongjun Chen, Chaoliu Dai, Rongping Guo, Wenzhi Guo, Chunyi Hao, Tao Huang, Zhiyong Huang, Deyu Li, Gang Li, Tao Li, Xiangcheng Li, Guangming Li, Xiao Liang, Jingfeng Liu, Fubao Liu, Shichun Lu, Zheng Lu, Weifu Lv, Yilei Mao, Guoliang Shao, Yinghong Shi, Tianqiang Song, Guang Tan, Yunqiang Tang, Kaishan Tao, Chidan Wan, Guangyi Wang, Lu Wang, Shunxiang Wang, Tianfu Wen, Baocai Xing, Bangde Xiang, Sheng Yan, Dinghua Yang, Guowen Yin, Tao Yin, Zhenyu Yin, Zhengping Yu, Bixiang Zhang, Jialin Zhang, Shuijun Zhang, Ti Zhang, Yamin Zhang, Yubao Zhang, Aibin Zhang, Haitao Zhao, Ledu Zhou, Wu Zhang, Zhenyu Zhu, Shukui Qin, Feng Shen, Xiujun Cai, Gaojun Teng, Jianqiang Cai, Minshan Chen, Qiang Li, Lianxin Liu, Weilin Wang, Tingbo Liang, Jiahong Dong, Xiaoping Chen, Xuehao Wang, Shusen Zheng, Jia Fan; Alliance of Liver Cancer Conversion Therapy, Committee of Liver Cancer of the Chinese Anti-Cancer Association
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:227-252
.
Therapeutic advances in advanced hepatocellular carcinoma have increased the opportunity for patients with initially unresectable disease to achieve tumor downstaging and undergo surgical resection, a ‘conversion therapy’. We reviewed current evidence for conversion therapy in HCC and developed expert consensus statements to guide clinical practice.
Novel biomarkers and the future of targeted therapies in cholangiocarcinoma: a narrative review
Nishant Munugala, Shishir K. Maithel, Rachna T. Shroff
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:253-266
.
Cholangiocarcinoma is a highly aggressive group of biliary malignancies with limited treatment options and poor overall survival. The advent of next generation sequencing has led to the identification of several new actionable mutations with significant implications for the diagnosis and treatment of this disease.

Editorial from the ACHBPT1

Comment on: “Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS Liver PROTECT randomized clinical trial
Arthur Marichez, Jean-Philippe Adam
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:267-269
.
Comment on: a multicentre outcome analysis to define global benchmarks for donation after circulatory death liver transplantation
Christian Hobeika, Mickaël Lesurtel, François Cauchy
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:270-272
.

Editorial

The internet hospital: how to combine with traditional healthcare model
Qunhua Zhang
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:273-275
.
The 11th revision of the International Statistical Classification of Disease and Related Health Problems and Cholangiocarcinoma
Shijie Cai, Shivan Sivakumar
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:276-279
.
Comment on: the tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma
Lixia Xu, Qingxia Yang, Ce Tang, Ming Kuang
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:280-282
.
Utilization of hepatitis B virus-positive allografts in liver transplantation: a new arrow to the bowstring for expanding the donor pool?
Gang Xu, Chen-Hao Jiang, Yao Xiao, Tao Lyu, Li Jiang, Lyu-Nan Yan, Jia-Yin Yang
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:283-287
.
Commentary on “The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma”
Li-Hong He, Xiao-Zhen Zhang, Kang Sun, Xue-Li Bai
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:288-291
.
“Digging in the Dirt” faecal microRNAs as dietary biomarkers of host-microbe interactions
Gerard M. Moloney, John F. Cryan, Gerard Clarke
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:292-294
.
Pancreatectomy with concomitant portal vein resection in the current neoadjuvant era
Benedetto Ielpo, Fernando Burdio, Ana Martinez, Patricia Sanchez-Velazquez
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:295-298
.
Metabolic dysfunction-associated fatty liver disease (MAFLD) and non-alcoholic fatty liver disease (NAFLD): distinct fatty liver entities with different clinical outcomes?
Eda Kaya, Aleko Zedginidze, Lars Bechmann, Ali Canbay
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:299-301
.
Positive pancreatic neck margins—a telltale sign of complex biology
Elie Ghabi, Jin He
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:302-304
.
Age-specific microbiota in altering host inflammatory and metabolic signaling and metabolome based on sex
Yunchao Wang, Huayu Yang, Haifeng Xu
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:305-307
.

Commentary

Surgery is the means of treatment, but high-quality survival is the ultimate goal
Penglei Ge, Yang Wu
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:308-310
.
Hidden-mortality risk among patients deemed “low-risk” following high-risk operations
Yongliang Sun, Wenquan Niu, Zhiying Yang
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:311-313
.
Comment on “Perihilar cholangiocarcinoma—novel benchmark values for surgical and oncological outcomes from 24 expert centers”
Yasunari Kawabata, Yoshitsugu Tajima
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:314-316
.
Nonalcoholic fatty liver disease in early life and all-cause and cause-specific mortality
Donghee Kim, Aijaz Ahmed
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:317-319
.
Drivers and breaks in the cholangiocarcinoma immune microenvironment
Caitlin B. Conboy, Sumera I. Ilyas, Gregory J. Gores
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:320-323
.
Loco-regional treatments of unresectable hepatocellular carcinoma: safety first
Jean-Luc Raoul
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:324-326
.
Immunotherapy for hepatocellular carcinoma: a “CRAFITY” approach to patient stratification
Salim I. Khakoo
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:327-329
.

Viewpoint

Safety and feasibility of laparoscopic pancreatoduodenectomy
Nobuhiko Nakagawa, Yuichi Nagakawa, Shingo Kozono
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:330-332
.

Letter to the Editor

Metabolic abnormalities play a crucial role in non-obese people suffering from non-alcoholic fatty liver disease (NAFLD)
Qing Ye, Takanori Ito, Linda Henry, Mindie H. Nguyen
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:333-334
.
Conversion therapy of stage IVb unresectable gallbladder carcinoma
Cong Ning, Xinmu Zhang, Xiaobo Yang, Xinting Sang, Haitao Zhao, Hanping Wang
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:335-337
.

News

Launching of the Sultan Qaboos Comprehensive Cancer Care and Research Center (SQCCCRC) in the Sultanate of Oman to manage HBP type of cancers
Abdallah Al Farai, Mansour Al Moundhri, Fabrizio Panaro
HepatoBiliary Surgery and Nutrition  
2022;
11
(2)
:338-339
.

Disclosure:

1. The series “Editorial from the ACHBPT” was commissioned by the editorial office, Hepatobiliary Surgery and Nutrition without any sponsorship or funding.