Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease

Liver cirrhosis and primary liver cancers are leading causes of mortality worldwide with over than 1.7 million of deaths in 2010 representing about 3.4% of the overall deaths (1). Global liver cirrhosis deaths ceaselessly increased by 52.2% from 1980 to 2010 (1). Similarly, primary liver cancers global deaths increased by 62.4% from 1990 to 2010 (2). Chronic viral (i.e., HBV and HCV), alcoholic (ALD) and non-alcoholic fatty liver (NAFLD) diseases are the most important etiologies of liver cirrhosis and hepatocellular carcinoma (HCC).