Vol 12, No 3 (June 01, 2023): Hepatobiliary Surgery and Nutrition

The Story Behind the Cover Picture

St. Francis of Assisi receives the stigma on his liver
Thomas M. van Gulik
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:300-301
.

Original Article

Targeted deep sequencing reveals the genetic heterogeneity in well-differentiated pancreatic neuroendocrine tumors with liver metastasis
Wentao Zhou, Xu Han, Yuan Ji, Dansong Wang, Dong Xie, Zilong Qiu, Wenhui Lou
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:302-313
.
The intratumor, intraindividual, and interindividual heterogeneity in pNET patients were discovered through the targeted deep sequencing in the surgically resected pNET and paired liver metastatic samples, which brought potential challenges for the current biopsy strategies in guiding the clinical treatments.
Association of tumor morphology with long-term prognosis after liver resection for patients with a solitary huge hepatocellular carcinoma—a multicenter propensity score matching analysis
Xin-Fei Xu, Han Wu, Ju-Dong Li, Lan-Qing Yao, Bin Huang, Yong-Kang Diao, Ting-Hao Chen, Wei-Min Gu, Zhong Chen, Jie Li, Yao-Ming Zhang, Hong Wang, Ying-Jian Liang, Ya-Hao Zhou, Chao Li, Ming-Da Wang, Cheng-Wu Zhang, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:314-327
.
This large-scale multicenter study demonstrated that preoperative imaging tumor morphology was associated with prognosis following resection for a solitary huge HCC. Patients with balloon-shaped HCCs had better overall survival and recurrence-free survival than patients with non-balloon-shaped HCCs after hepatectomy.
Impact of pure laparoscopic surgery on bile duct division of living donor left lateral section procurement
Hai-Ming Zhang, Lin Wei, Hong-Yu Li, Li-Ying Sun, Wei Qu, Zhi-Gui Zeng, Ying Liu, Zhi-Jun Zhu
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:328-340
.
A high frequency of multiple bile ducts was found in a sample of 74 laparoscopic left lateral section liver procurements as compared with 106 in open surgery left lateral section liver procurements. Use of routine X-ray based intraoperative cholangiography may help to reduce this problem.
Adipose tissue induces a better liver regeneration after living liver donation in normal weight donors
Aladdin Ali Deeb, Utz Settmacher, Michael Ardelt, Felix Dondorf, Oliver Rohland, Falk Rauchfuß
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:341-350
.
Regenerating liver hepatocytes normally accumulate fat microdroplets. The extrahepatic adipose tissue could be an important factor affecting liver regeneration after partial hepatectomy. In this study, we found that living donors with a higher fat mass index had a better liver volume gain after surgery.
Large, multifocal or portal vein-invading hepatocellular carcinoma (HCC) downstaged by Y90 using personalized dosimetry: safety, pathological results and outcomes after surgery
Mohamad Azhar Meerun, Carole Allimant, Benjamin Rivière, Astrid Herrero, Fabrizio Panaro, Eric Assenat, Christophe Cassinotto, Denis Mariano-Goulart, Boris Guiu
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:351-365
.
Our study showed that Y90 TARE using personalized dosimetry can provide high rates of imaging and pathological response in patients with PVTT, large or multifocal HCC. Subsequent surgery is safe and leads to outcomes that far exceed expectations in a population with an otherwise poor prognosis and no chance for cure.

Review Article

The Hong Kong consensus statements on unresectable hepatocellular carcinoma: narrative review and update for 2021
Tan-To Cheung, Simon Chun-Ho Yu, Stephen L. Chan, Ronnie T. P. Poon, Philip Kwok, Ann-Shing Lee, Anna Tai, Derek Tam, Chin-Cheung Cheung, Tak-Wing Lai, Nam-Hung Chia, Ada Law, Tracy Shum, Yim-Kwan Lam, Vince Lau, Victor Lee, Charing Chong, Chung-Ngai Tang, Thomas Yau
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:366-385
.
These statements summarize expert opinion on the treatment of hepatocellular carcinoma, including the use of surgical, transarterial, ablative, radiotherapeutic and systemic modalities. This update has seen additions guiding the use of targeted therapies and immunotherapies due to the availability of new data.

Expert Consensus

An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease
Dan-Qin Sun, Giovanni Targher, Christopher D. Byrne, David C. Wheeler, Vincent Wai-Sun Wong, Jian-Gao Fan, Herbert Tilg, Wei-Jie Yuan, Christoph Wanner, Xin Gao, Michelle T. Long, Mehmet Kanbay, Mindie H. Nguyen, Sankar D. Navaneethan, Yusuf Yilmaz, Yuli Huang, Rino A. Gani, Pierluigi Marzuillo, Jérôme Boursier, Huijie Zhang, Chan-Young Jung, Jin Chai, Luca Valenti, George Papatheodoridis, Giovanni Musso, Yu-Jun Wong, Mohamed El-Kassas, Nahum Méndez-Sánchez, Silvia Sookoian, Michael Pavlides, Ajay Duseja, Adriaan G. Holleboom, Junping Shi, Wah-Kheong Chan, Yasser Fouad, Junwei Yang, Sombat Treeprasertsuk, Helena Cortez-Pinto, Masahide Hamaguchi, Manuel Romero-Gomez, Mamun Al Mahtab, Ponsiano Ocama, Atsushi Nakajima, Chunsun Dai, Mohammed Eslam, Lai Wei, Jacob George, Ming-Hua Zheng
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:386-403
.
Using a Delphi-based approach, a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on epidemiology, mechanisms, management and treatment between MAFLD and CKD, to provide a framework for the development of appropriate guidance on CKD in individuals with MAFLD.

French Editorial Commentary from the ACHBPT

Feasibility, safety and limits of robotic approach for lymphadenectomy in biliary tumours
Julie Deyrat, Stylianos Tzedakis
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:404-406
.

Editorial Commentary

The difficulty of medical decision-making: should patients be involved?
Junbin Zhou, Xiao Xu
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:407-409
.
Bleeding risk and thrombosis in cirrhosis: a paradox with a need to address them
Anand V. Kulkarni, K. Rajender Reddy
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:410-412
.
How will the latest modifications to the CG189 NICE guidelines for obesity management likely impact clinical care?
Thomas M. Barber
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:413-416
.
Sarcopenic obesity: recent consensus and clinical implications in patients with chronic liver disease
Manuela Merli, Saniya Khan
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:417-420
.
Screening for pancreatic cancer in individuals with genetic susceptibility
Robert Grützmann, Maximilian Brunner
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:421-423
.
Liver transplantation for non-resectable colorectal metastases—an evolving paradigm in transplant oncology
Christian Hobeika, Markus Selzner
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:424-427
.
Pancreatic exocrine insufficiency guidelines: more questions than answers!
Nikhil Bush, Vikesh K. Singh
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:428-430
.
Proposal of definition and diagnostic criteria for sarcopenic obesity by ESPEN and EASO
Toshimi Kaido
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:431-434
.
Adjuvant atezolizumab-bevacizumab after curative therapy for hepatocellular carcinoma
Masatoshi Kudo
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:435-439
.
Time-restricted feeding: what we have done and what more we can do?
Yuning Sun, Yuqian Ye, Yuqin He, Shaoyan Liu
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:440-442
.

Editorial

Resection vs. transplantation for hepatocellular carcinoma: a never ending challenge
Joana Ferrer-Fàbrega, Jordi Bruix
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:443-446
.
Hepatic inflammation: an important target for biomarker development in nonalcoholic fatty liver disease
Hiba Khan, Mohammad Shadab Siddiqui
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:447-449
.
β-cryptoxanthin and fatty liver disease: new insights
Robin D. Clugston
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:450-452
.
Development of conversion therapy for advanced hepatocellular carcinoma
Ryota Matsuki, Masaharu Kogure, Nobuhiro Hasui, Hirokazu Momose, Yutaka Suzuki, Yoshihiro Sakamoto
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:453-456
.
The promise of precision medicine: how biomarkers are shaping the future of cholangiocarcinoma treatment
Rocio I. R. Macias, Lorenza Rimassa, Angela Lamarca
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:457-461
.
Qualifying the suitability of living donor livers for pediatric liver transplantation: are we doing the right thing?
Henkjan J. Verkade, Frans C. J. Cuperus, Aad P. van den Berg
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:462-464
.
Preservation of aberrant right hepatic artery during pancreaticoduodenectomy
Takamune Yamaguchi, Nermin Halkic
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:465-467
.

Letter to the Editor

Multikinase inhibitor-based immunotherapy doublet for advanced hepatocellular carcinoma: its efficacy still needs to be determined
Heming Li, Xiangjun Hao, Tao Han
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:468-471
.
Is transarterial embolization plus two-stage hepatectomy the optimal strategy for the treatment of spontaneous rupture of hepatocellular carcinoma?
Tao He, Jieyu Zou
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:472-474
.
Revision and addendum to the manuscript titled “Propensity score matching study of 325 patients with spontaneous rupture of hepatocellular carcinoma
Wei Wang, Tao Meng, Ying Chen, Ye-Chuan Xu, Yi-Jun Zhao, Yan Zhang, Ming-Ya Yang, Zhi-Hua Zhang, Fan Huang, Hong-Chuan Zhao, Xiao-Ping Geng, Li-Xin Zhu
HepatoBiliary Surgery and Nutrition  
2023;
12
(3)
:475-477
.