Vol 13, No 4 (August 01, 2024) - Hepatobiliary Surgery and Nutrition

Original Article

The application of real-time indocyanine green fluorescence cholangiography in laparoscopic living donor left lateral sectionectomy

Lu Lu, Wen-Wei Zhu, Cong-Huan Shen, Yi-Feng Tao, Zheng-Xin Wang, Jin-Hong Chen, Lun-Xiu Qin

PDF Pages: 575-585 Full Text (525) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

ICG fluorescence cholangiography avoided the biliary complications in both donors and its relevant recipients and is recommended for routine use in LLLS.

Immunosuppression and phenotypic plasticity in an atlas of human hepatocholangiocarcinoma

Yiran Li, Ziyu Xun, Junyu Long, Huishan Sun, Xu Yang, Yanyu Wang, Yunchao Wang, Jingnan Xue, Nan Zhang, Junwei Zhang, Jin Bian, Jie Shi, Xiaobo Yang, Hanping Wang, Haitao Zhao

PDF Pages: 586-603 Full Text (1419) COI Form Open Access

We used single-cell RNA sequencing data analysis to systematically compare the transcriptomic signatures of different cell populations in HCC, iCCA and H-ChC, which revealed the molecular mechanisms underlying the coexistence of HCC and iCCA components in H-ChC.

The differential benefit of laparoscopic over open minor liver resection for lesions situated in the anterolateral or posterosuperior segments

Jasper P. Sijberden, Guido Fiorentini, Jacopo Lanari, Davit Aghayan, Daniel Osei-Bordom, Nadia Russolillo, Arjun Takhar, Andrea Benedetti Cacciaguerra, Santi Lopez-Ben, Mathieu D’Hondt, Felice Giuliante, David Fuks, Fernando Rotellar, Andrea Ruzzenente, Adnan Alseidi, Mikhail Efanov, Burak Görgec, Giuseppe Zimmitti, Enrico Gringeri, Federica Cipriani, Åsmund Avdem Fretland, Ravi Marudanayagam, Marco Vivarelli, John N. Primrose, Alessandro Ferrero, Robert P. Sutcliffe, Bjørn Edwin, Umberto Cillo, Marc G. Besselink, Mohammad Abu Hilal, Luca A. Aldrighetti

PDF Pages: 604-615 Full Text (480) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Laparoscopic surgery offers several benefits over open surgery when adopted for minor liver resections in the AL and PS segments. The advantage of laparoscopy is however greater in the AL segments. In centers with the appropriate experience, the minimally invasive approach should thus increasingly be adopted to perform minor liver resections irrespective of the location of the lesion(s).

Adjuvant camrelizumab plus apatinib in resected hepatocellular carcinoma with microvascular invasion: a multi-center real world study

Jingzhong Ouyang, Yi Yang, Yanzhao Zhou, Xu Chang, Zhengzheng Wang, Qingjun Li, Yu Tang, Jianqiang Cai, Jinxue Zhou, Zhen Huang, Hong Zhao

PDF Pages: 616-631 Full Text (1040) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Camrelizumab plus Apatinib has shown significant efficacy in improving RFS as a postoperative adjuvant regimen for patients with MVI-positive HCC. The favorable safety makes the combination an alternative adjunctive regimen for HCC patients after hepatectomy.

Specific metabolic impairments indicate loss of sustained liver improvements in metabolic dysfunction-associated steatotic liver disease treatment

Ling Luo, Junzhao Ye, Shuyu Zhuo, Bo Ma, Weiyi Mai, Xiaopei Cao, Liuqin Liang, Wei Wang, Shiting Feng, Zhi Dong, Bihui Zhong

PDF Pages: 632-649 Full Text (458) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Residual insulin resistance and high total bile acid levels were identified as risk factors for subsequent diminished sustained improvements of steatosis and fibrosis in MASLD patients, respectively. This provides potential guidance for clinicians in preventing patients against loss of treatment response in MASLD.

Review Article

A literature review of genetics and epigenetics of HCV-related hepatocellular carcinoma: translational impact

Ziyan Pan, Wai-Kay Seto, Chun-Jen Liu, Yilei Mao, Saleh A. Alqahtani, Mohammed Eslam

PDF Pages: 650-661 Full Text (765) Reporting Checklist Peer Review File COI Form Open Access

This review provides a comprehensive and updated review of research on the genetics and epigenetic mechanisms implicated in developing Hepatocellular carcinoma (HCC) associated with Hepatitis C infection (HCV) infection. We also discuss the potential translational implications, including novel biomarkers and drugs for treatment.

Surgical Technique

Beyond the Rex: an innovative meso-intrahepatic portal vein bypass for late-onset extrahepatic portal vein occlusion after living donor liver transplantation

Chee-Chien Yong, Hsu-Ting Yen, Yu-Fan Cheng, Leona Bettina Dungca, Raymond Joseph De Vera, Itsuko Chih-Yi Chen, Chao-Long Chen

PDF Pages: 662-668 Full Text (503) Reporting Checklist Peer Review File COI Form Open Access

The MIPVB is an innovative technique to address EHPVO especially in patients with a Rex recess that is not safely accessible and with symptoms refractory to conventional surgical strategies. Furthermore, it is potentially useful for the right liver graft.